ACTR-I Activators
ACTR-I, or Activator of Transcription and Chromatin Remodeling I, is a multifunctional protein involved in regulating gene expression and chromatin structure within the cell nucleus. Its primary function revolves around facilitating the transcriptional process by interacting with various transcription factors, co-regulators, and chromatin remodeling complexes. Through these interactions, ACTR-I modulates the activity of RNA polymerase II, the enzyme responsible for transcribing DNA into RNA, thereby influencing the expression of protein-coding genes. Additionally, ACTR-I participates in chromatin remodeling processes, which involve modifying the structure of chromatin to either facilitate or inhibit access to DNA by the transcriptional machinery. This chromatin remodeling activity is crucial for regulating gene expression patterns in response to developmental cues, environmental stimuli, and cellular signaling pathways.
Activation of ACTR-I typically occurs through complex signaling cascades initiated by extracellular stimuli or intracellular signaling pathways. These signaling events lead to post-translational modifications of ACTR-I, such as phosphorylation, acetylation, or methylation, which regulate its activity and subcellular localization. Additionally, activation of specific transcription factors or co-regulators can induce conformational changes in ACTR-I, promoting its interaction with other components of the transcriptional machinery and chromatin remodeling complexes. Furthermore, ACTR-I activation may also involve its recruitment to specific genomic loci through interactions with DNA-binding proteins or non-coding RNAs, leading to the initiation of transcriptional programs associated with cellular differentiation, proliferation, or response to stress. Overall, the activation of ACTR-I is tightly regulated and orchestrated by a network of cellular signaling pathways and protein-protein interactions to ensure precise control over gene expression dynamics in the cell.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased levels of cAMP. Elevated cAMP activates protein kinase A (PKA), which can modulate ACTR-I through downstream signaling events. The indirect activation of ACTR-I by Forskolin underscores the importance of cAMP/PKA signaling in influencing ACTR-I function within cellular processes. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore that raises intracellular calcium levels. Elevated calcium concentrations can activate various signaling pathways, potentially influencing ACTR-I through calcium-dependent mechanisms. The indirect activation of ACTR-I by A23187 highlights the intricate interplay between calcium signaling and ACTR-I function within cellular processes. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). PKC activation can modulate multiple signaling pathways, potentially influencing ACTR-I. The indirect activation of ACTR-I by PMA emphasizes the regulatory role of PKC and its downstream effects on ACTR-I within cellular processes. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $84.00 $196.00 $817.00 | ||
Bay K8644 is a calcium channel activator, leading to increased intracellular calcium levels. The elevation in calcium concentrations can activate diverse signaling cascades, potentially influencing ACTR-I through calcium-dependent pathways. The indirect activation of ACTR-I by Bay K8644 highlights the intricate interplay between calcium signaling and ACTR-I function within cellular processes. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Bromo-cAMP is a cell-permeable analog of cAMP. Its introduction elevates intracellular cAMP levels, activating PKA and potentially influencing ACTR-I through downstream signaling events. The indirect activation of ACTR-I by 8-Bromo-cAMP emphasizes the regulatory role of cAMP/PKA signaling and its downstream effects on ACTR-I within cellular processes. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels. Elevated calcium concentrations can activate various signaling pathways, potentially influencing ACTR-I through calcium-dependent mechanisms. The indirect activation of ACTR-I by Ionomycin highlights the intricate interplay between calcium signaling and ACTR-I function within cellular processes. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $184.00 $741.00 $1076.00 $3417.00 $5304.00 | 23 | |
A-769662 is an AMP-activated protein kinase (AMPK) activator. Activation of AMPK can influence various cellular pathways, potentially modulating ACTR-I through downstream signaling events. The indirect activation of ACTR-I by A-769662 highlights the regulatory role of AMPK and its downstream effects on ACTR-I within cellular processes. | ||||||
4α-Phorbol 12,13-didecanoate | 27536-56-7 | sc-201210 sc-201210A | 1 mg 5 mg | $188.00 $676.00 | 3 | |
4α-Phorbol 12,13-didecanoate is an activator of protein kinase C (PKC). PKC activation can modulate various signaling pathways, potentially influencing ACTR-I. The indirect activation of ACTR-I by 4α-Phorbol 12,13-didecanoate underscores the regulatory role of PKC and its downstream effects on ACTR-I within cellular processes. | ||||||
NS309 | 18711-16-5 | sc-253202 | 5 mg | $110.00 | ||
NS309 is an activator of small-conductance calcium-activated potassium (SK) channels. SK channel activation can modulate calcium signaling, potentially influencing ACTR-I through calcium-dependent mechanisms. The indirect activation of ACTR-I by NS309 highlights the intricate interplay between SK channels and ACTR-I function within cellular processes. | ||||||