ACSF3 Inhibitors
ACSF3 inhibitors of ATP-citrate lyase, such as Hydroxycitrate, can reduce the production of acetyl-CoA, a substrate involved in ACSF3 activity. By interfering with the production or availability of acyl-CoA species, these inhibitors can indirectly modulate the function of ACSF3. Compounds like Etomoxir and Perhexiline affect fatty acid metabolism, which is closely related to the acyl-CoA pool within mitochondria.
By modulating this pool, these inhibitors can alter the activity of ACSF3. Malonate and Sodium fluoroacetate target the tricarboxylic acid (TCA) cycle and related metabolic processes, which can lead to an accumulation or reduction of specific intermediates that influence ACSF3's function. Metal chelators like 2-Thenoyltrifluoroacetone could affect the metal-dependent enzymes of the mitochondria, potentially impacting ACSF3 as well. Mitochondrial function modulators such as Oligomycin and Chloroquine alter the mitochondrial membrane potential and bioenergetics, which can indirectly influence ACSF3's activity by changing the energetic milieu.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(+)-Etomoxir sodium salt | 828934-41-4 | sc-215009 sc-215009A | 5 mg 25 mg | $151.00 $506.00 | 3 | |
Inhibits carnitine palmitoyltransferase-1 (CPT1), potentially reducing fatty acyl-CoA levels, which may decrease ACSF3 substrate availability. | ||||||
2-Thenoyltrifluoroacetone | 326-91-0 | sc-251801 | 5 g | $37.00 | 1 | |
Inhibits various mitochondrial enzymes by chelating metal cofactors, potentially affecting ACSF3 activity. | ||||||
Sodium phenylbutyrate | 1716-12-7 | sc-200652 sc-200652A sc-200652B sc-200652C sc-200652D | 1 g 10 g 100 g 1 kg 10 kg | $77.00 $166.00 $622.00 $5004.00 $32783.00 | 43 | |
By donating phenyl groups, it can potentially modulate coenzyme A levels within mitochondria, affecting ACSF3 substrate availability. | ||||||
rac Perhexiline Maleate | 6724-53-4 | sc-460183 | 10 mg | $188.00 | ||
Modulates lipid metabolism by inhibiting mitochondrial carnitine palmitoyltransferase-2 (CPT2), which can alter acyl-CoA levels and thus ACSF3 activity. | ||||||
Sulfosuccinimidyl oleate sodium | 135661-44-8 | sc-208408B sc-208408 sc-208408A sc-208408C | 10 mg 25 mg 50 mg 250 mg | $245.00 $418.00 $734.00 $2913.00 | 17 | |
Inhibits fatty acid transport into mitochondria, potentially reducing the substrate availability for ACSF3. | ||||||
Oligomycin | 1404-19-9 | sc-203342 sc-203342C | 10 mg 1 g | $149.00 $12495.00 | 18 | |
Inhibits ATP synthase, potentially affecting mitochondrial ATP levels and thus the energy status required for ACSF3's activity. | ||||||
O-(Carboxymethyl)hydroxylamine hemihydrochloride | 2921-14-4 | sc-207410B sc-207410 sc-207410A | 250 mg 1 g 10 g | $55.00 $107.00 $320.00 | ||
Inhibits aminotransferases, potentially affecting the levels of amino acids and keto acids that can influence mitochondrial metabolism and ACSF3 activity. | ||||||
Triacsin C Solution in DMSO | 76896-80-5 | sc-200574 sc-200574A | 100 µg 1 mg | $187.00 $843.00 | 14 | |
Inhibits long-chain acyl-CoA synthetase, potentially decreasing the availability of acyl-CoA substrates for ACSF3. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
A lysosomotropic agent known to alter mitochondrial function, which may indirectly affect ACSF3 activity. | ||||||