Molecular structure of Sulfosuccinimidyl oleate sodium, CAS Number: 135661-44-8
Sulfosuccinimidyl oleate sodium (CAS 135661-44-8)
See product citations (17)
Alternate Names:
Sulfosuccinimidyl oleate sodium is also known as SSO.
Application:
Sulfosuccinimidyl oleate sodium is a long-chain fatty acid that irreversibly inhibits fatty acid translocase CS36 transport.
CAS Number:
135661-44-8
Purity:
≥96%
Molecular Weight:
481.58
Molecular Formula:
C22H36NO7S•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Sulfosuccinimidyl Oleate Sodium (SSO) is a long-chain fatty acid that irreversibly inhibits fatty acid translocase CS36 transport. It blocks uptake of oleate, linoleate, or stearate by about 65% when added at 200 µM to adipocytes. Sulfosuccinimidyl Oleate Sodium reduces the uptake of palmitate by mouse insulinoma MIN6 cells, preventing palmitate-induced changes in insulin secretion. In RAW 264.7 macrophages, Sulfosuccinimidyl Oleate Sodium was shown to impair saturated fatty acid-induced lipid accumulation and inflammation.
Sulfosuccinimidyl oleate sodium (CAS 135661-44-8) References
- Electrostimulation enhances FAT/CD36-mediated long-chain fatty acid uptake by isolated rat cardiac myocytes. | Luiken, JJ., et al. 2001. Am J Physiol Endocrinol Metab. 281: E704-12. PMID: 11551846
- Fatty acid translocase (FAT/CD36) is localized on insulin-containing granules in human pancreatic beta-cells and mediates fatty acid effects on insulin secretion. | Noushmehr, H., et al. 2005. Diabetes. 54: 472-81. PMID: 15677505
- Labeling of adipocyte membranes by sulfo-N-succinimidyl derivatives of long-chain fatty acids: inhibition of fatty acid transport. | Harmon, CM., et al. 1991. J Membr Biol. 121: 261-8. PMID: 1865490
- Hematopoietic cell-restricted deletion of CD36 reduces high-fat diet-induced macrophage infiltration and improves insulin signaling in adipose tissue. | Nicholls, HT., et al. 2011. Diabetes. 60: 1100-10. PMID: 21378177
- CD36 is involved in lycopene and lutein uptake by adipocytes and adipose tissue cultures. | Moussa, M., et al. 2011. Mol Nutr Food Res. 55: 578-84. PMID: 21462325
- CD36 is involved in high glucose-induced epithelial to mesenchymal transition in renal tubular epithelial cells. | Hou, Y., et al. Biochem Biophys Res Commun. 468: 281-6. PMID: 26505798
- Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation. | Dhungana, H., et al. 2017. J Neuroinflammation. 14: 237. PMID: 29202856
- STAT3-activated CD36 facilitates fatty acid uptake in chronic lymphocytic leukemia cells. | Rozovski, U., et al. 2018. Oncotarget. 9: 21268-21280. PMID: 29765537
- Inhibition of Fatty Acid Synthase Upregulates Expression of CD36 to Sustain Proliferation of Colorectal Cancer Cells. | Drury, J., et al. 2020. Front Oncol. 10: 1185. PMID: 32850342
- Demonstration by covalent cross-linking of a specific interaction between beta-endorphin and calmodulin. | Giedroc, DP., et al. 1983. J Biol Chem. 258: 16-9. PMID: 6294097
- Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. Homology with human CD36. | Abumrad, NA., et al. 1993. J Biol Chem. 268: 17665-8. PMID: 7688729
- Reversible binding of long-chain fatty acids to purified FAT, the adipose CD36 homolog. | Baillie, AG., et al. 1996. J Membr Biol. 153: 75-81. PMID: 8694909
- Fatty acid transport: difficult or easy? | Hamilton, JA. 1998. J Lipid Res. 39: 467-81. PMID: 9548581
Inhibitor of:
ACSF3, DGAT2L6, and SLC4A (Solute carrier family 4).Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sulfosuccinimidyl oleate sodium, 10 mg | sc-208408B | 10 mg | $240.00 | |||
Sulfosuccinimidyl oleate sodium, 25 mg | sc-208408 | 25 mg | $410.00 | |||
Sulfosuccinimidyl oleate sodium, 50 mg | sc-208408A | 50 mg | $720.00 | |||
Sulfosuccinimidyl oleate sodium, 250 mg | sc-208408C | 250 mg | $2856.00 |