ACMSD Activators
ACMSD activators mainly operate through modulation of pathways that affect the NAD biosynthesis route. Chemicals like AICAR and Metformin activate AMPK, a sensor of cellular energy status, thus influencing the activity of ACMSD by upregulating the metabolic pathways involved in NAD synthesis. Likewise, compounds like NAD+ and Quercetin might exert influence through substrate-product relationships and substrate availability, respectively. These chemicals can essentially enhance ACMSD activation by increasing the overall flux of intermediates in the pathway where ACMSD operates.
Moreover, there are activators like Resveratrol and Caffeine that operate through different mechanisms. Resveratrol's activation of SIRT1 increases the consumption of NAD+, creating a scenario for elevated pathway flux. Caffeine, on the other hand, affects cAMP levels which in turn could affect metabolic enzymes, including those in the NAD synthesis pathway. Other cofactors like Zinc and Selenium offer enzymatic optimization, which is a distinct method of indirect activation. The focus here is primarily on increasing substrate availability, optimizing cofactor interaction, or influencing upstream enzymes to ensure the activation of ACMSD.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
Activates AMPK, which can upregulate metabolic pathways involved in NAD synthesis. This could increase the overall flux through the pathway where ACMSD is involved, leading to its activation. | ||||||
Metformin-d6, Hydrochloride | 1185166-01-1 | sc-218701 sc-218701A sc-218701B | 1 mg 5 mg 10 mg | $286.00 $806.00 $1510.00 | 1 | |
Also activates AMPK. By increasing NAD biosynthesis pathway flux, ACMSD can experience enhanced activation. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Inhibits NADPH oxidase, which could increase available NADPH. This can indirectly affect ACMSD's activity by increasing substrate availability. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Activates SIRT1, which uses NAD+. This can result in increased flux through the pathway and therefore activation of ACMSD. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Inhibits phosphodiesterases, elevating cAMP. cAMP activation could potentially affect enzymes in the NAD biosynthesis pathway, indirectly activating ACMSD. | ||||||
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $70.00 $180.00 | 1 | |
Involved in electron transport chain. Increasing ETC efficiency can boost NADH to NAD+ conversion, possibly leading to increased ACMSD activation through elevated pathway flux. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Acts as a cofactor for various enzymes. If ACMSD requires such cofactor availability for optimal activity, Zinc supplementation can activate ACMSD. | ||||||
Selenium | 7782-49-2 | sc-250973 | 50 g | $61.00 | 1 | |
A trace element that serves as a cofactor for redox enzymes. Enhanced redox balance can positively influence ACMSD activity. | ||||||
L-Carnitine | 541-15-1 | sc-205727 sc-205727A sc-205727B sc-205727C | 1 g 5 g 100 g 250 g | $23.00 $33.00 $77.00 $175.00 | 3 | |
Involved in fatty acid metabolism and affects the acetyl-CoA to CoA ratio. Changes in CoA can affect NAD synthesis pathways and therefore indirectly activate ACMSD. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Activates TRPV1, leading to calcium influx. Calcium signaling could affect metabolic enzyme regulation, potentially activating ACMSD. | ||||||