ACAT-2 Activators
ACAT-2 Activators encompass a diverse set of chemical compounds that serve to augment the functional activity of ACAT-2 through various biochemical mechanisms. For instance, Forskolin and 8-Bromo-cAMP boost intracellular cAMP, which activates protein kinase A (PKA) and can lead to the phosphorylation of proteins that interact with ACAT-2, thus enhancing its enzymatic role in cholesterol esterification. Similarly, Oleic Acid and Squalene provide a substrate for ACAT-2, which facilitates its activity in esterifying cholesterol, while 5-Aminolevulinic acid could increase cholesterol demand in mitochondria, indirectly promoting ACAT-2 action. Pregnenolone and Geranylgeranyl pyrophosphate, by their roles in steroidogenesis and protein prenylation, respectively, may upregulate ACAT-2 activity to meet the cellular needs for cholesterol-derived molecules. Additionally, modulators of cholesterol homeostasis, such as Cholic Acid, may enhance ACAT-2 activity by stimulating cholesterol turnover for bile acid synthesis.
Furthermore, compounds like LXR agonists GW3965 and T0901317 indirectly augment ACAT-2 function by upregulating genes in cholesterol metabolism, which could lead to increased cholesterol transport and efflux, enhancing the esterification function of ACAT-2. Pioglitazone, through PPAR-gamma agonism, alters lipid metabolism pathways which can incidentally upregulate ACAT-2 activity. Lastly, Retinoic Acidcould stimulates ACAT-2 activity by increasing the demand for cholesterol in the membranes during cell differentiation. Collectively, these activators work through distinct yet complementary mechanisms to enhance the functional activity of ACAT-2 without directly upregulating its expression or activating the protein in a direct fashion. Instead, they modulate the biochemical landscape in which ACAT-2 operates, ensuring that the protein's enzymatic activity related to cholesterol esterification is heightened in response to the cellular metabolic requirements.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin increases intracellular cAMP levels, which in turn activates PKA. PKA phosphorylates various proteins, potentially including those that interact with ACAT-2, enhancing its enzyme activity related to cholesterol esterification. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that activates PKA. PKA activation could lead to phosphorylation events enhancing ACAT-2 activity and its role in lipid metabolism. | ||||||
5-Aminolevulinic Acid Hydrochloride Salt | 5451-09-2 | sc-262399 sc-262399A sc-262399B sc-262399C | 1 g 5 g 25 g 100 g | $41.00 $110.00 $320.00 $1400.00 | 2 | |
As a precursor in the heme biosynthesis pathway, 5-Aminolevulinic acid might increase the demand for cholesterol in mitochondrial membranes, indirectly upregulating ACAT-2 activity to produce cholesterol esters. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $37.00 $104.00 $580.00 $1196.00 | 10 | |
Oleic Acid, a monounsaturated fatty acid, can be esterified by ACAT-2. An increase in substrate availability can enhance ACAT-2 activity in the esterification of cholesterol. | ||||||
Pregnenolone | 145-13-1 | sc-204860 sc-204860A sc-204860B sc-204860C | 5 g 25 g 100 g 500 g | $87.00 $148.00 $347.00 $1122.00 | ||
Pregnenolone is synthesized from cholesterol and may enhance ACAT-2 activity by increasing substrate turnover within the sterol regulatory element-binding protein (SREBP) pathway. | ||||||
Squalene | 111-02-4 | sc-281155 sc-281155A sc-281155B | 10 ml 100 ml 500 ml | $49.00 $92.00 $215.00 | 1 | |
Squalene, which is part of the cholesterol synthesis pathway, may indirectly enhance ACAT-2 activity by modulating cellular cholesterol levels and feedback mechanisms. | ||||||
Geranylgeranylpyrophosphate triammonium salt | 6699-20-3 | sc-200849 | 200 µg | $122.00 | ||
As a precursor for protein prenylation, increased levels of Geranylgeranyl pyrophosphate may enhance ACAT-2 activity due to augmented requirements for cholesterol in cell membranes. | ||||||
Cholic acid | 81-25-4 | sc-255020 sc-255020A sc-255020B sc-255020C sc-255020D | 25 g 100 g 500 g 1 kg 5 kg | $49.00 $123.00 $578.00 $1018.00 $4570.00 | 11 | |
Cholic Acid, a bile acid, can regulate cholesterol homeostasis. Its presence may enhance ACAT-2 activity by promoting cholesterol turnover and esterification for bile acid production. | ||||||
GW 3965 hydrochloride | 405911-17-3 | sc-224011 sc-224011A sc-224011B | 5 mg 25 mg 1 g | $140.00 $483.00 $3121.00 | ||
GW3965 activates liver X receptors (LXR) which can upregulate genes involved in cholesterol metabolism, indirectly enhancing ACAT-2 activity by increasing cholesterol efflux and transport. | ||||||
T 0901317 | 293754-55-9 | sc-202824 sc-202824A | 10 mg 50 mg | $89.00 $224.00 | 5 | |
T0901317 is an LXR agonist that can lead to increased expression of proteins in the cholesterol efflux pathway, potentially enhancing ACAT-2 activity by elevating intracellular cholesterol transport. | ||||||