ACAT-2 Antibody (4A5): sc-293307

ACAT-2 Antibody (4A5) is a mouse monoclonal IgG2a kappa light chain antibody that detects ACAT-2 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-ACAT-2 antibody (4A5) is available as a non-conjugated format. ACAT-2, also known as acetyl-CoA transferase-like protein or cytosolic acetoacetyl-CoA thiolase, plays a crucial role in lipid metabolism by catalyzing the reversible conversion of acetoacetyl-CoA to two acetyl-CoA molecules, which is essential for energy production and metabolic regulation. This 397 amino acid protein belongs to the thiolase family and functions as a homotetramer, highlighting structural importance in maintaining enzymatic activity. Proper functioning of ACAT-2 is vital for the synthesis and degradation of ketone bodies, which are key energy sources during periods of fasting or low carbohydrate intake. Dysregulation of ACAT-2 can lead to metabolic disorders, making ACAT-2 a significant target for research in metabolic diseases and potential therapeutic interventions.

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ACAT-2 Antibody (4A5) References:

1. Phylogenetic analysis of the thiolase family. Implications for the evolutionary origin of peroxisomes.  |  Igual, JC., et al. 1992. J Mol Evol. 35: 147-55. PMID: 1354266
2. Crystallographic and kinetic studies of human mitochondrial acetoacetyl-CoA thiolase: the importance of potassium and chloride ions for its structure and function.  |  Haapalainen, AM., et al. 2007. Biochemistry. 46: 4305-21. PMID: 17371050
3. A patient with severe neurologic symptoms and acetoacetyl-CoA thiolase deficiency.  |  Groot, CJ., et al. 1977. Pediatr Res. 11: 1112-6. PMID: 20597
4. The human homologue of the mouse t-complex gene, TCP1, is located on chromosome 6 but is not near the HLA region.  |  Willison, K., et al. 1987. EMBO J. 6: 1967-74. PMID: 3653076
5. Two acetyl-CoA acetyltransferase genes located in the t-complex region of mouse chromosome 17 partially overlap the Tcp-1 and Tcp-1x genes.  |  Ashworth, A. 1993. Genomics. 18: 195-8. PMID: 7904580
6. Molecular cloning and nucleotide sequence of complementary DNA for human hepatic cytosolic acetoacetyl-coenzyme A thiolase.  |  Song, XQ., et al. 1994. Biochem Biophys Res Commun. 201: 478-85. PMID: 7911016
7. Assignment of the human cytosolic acetoacetyl-coenzyme A thiolase (ACAT2) gene to chromosome 6q25.3-q26.  |  Masuno, M., et al. 1996. Genomics. 36: 217-8. PMID: 8812443

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ACAT-2 Antibody (4A5) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-ACAT-2 Antibody (4A5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ACAT-2 Antibody (4A5) Specifications

Alternate Product Name: ACAT-2

Product Clone Name: 4A5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-397

Epitope Target: ACAT-2

Epitope Species: human

Product Reactivity/Detection: ACAT-2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for ACAT-2 Antibody (4A5): N/A