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Squalene is a biosynthetic precursor for all steroids that is cytoprotective to normal cells exposed to carcinogens and antitumor agents.
Das, B., et al., In vitro cytoprotective activity of squalene on a bone marrow versus neuroblastoma model of cisplatin-induced toxicity. implications in cancer chemotherapy. Eur. J. Cancer 39, 2556-2565, (2003); Tansey, T.R., and Shechter, I., Structure and regulation of mammalian squalene synthase. Biochim. Biophys. Acta 1529, 49-62, (2000); Smith, T.J., Squalene: potential chemopreventive agent. Expert Opin. Investig. Drugs 9, 1841-1848, (2000)
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