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BaettaBaetta, R. et al. (PubMed 25849951) found that atrovasratin decreased the production and release of PTX3 in human endothelial cells (hEC) through a post-transcriptional effect. Co-incubation with mevalonate and Geranylgeranyl Pyrophosphate (a geranylgeranyl-donor molecule utilized by geranylgeranyltransferase) prevented this effect. This suggests that statins may interfere with PTX3 expression in vascular cells via inhibition of protein geranylgeranylation. -SCBT Publication Review
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