Geranylgeranylpyrophosphate triammonium salt (CAS 6699-20-3)
QUICK LINKS
Geranylgeranylpyrophosphate is a key intermediate in the biosynthesis of various important molecules, including proteins involved in cell signaling and regulation. It serves as a substrate for the enzyme geranylgeranyltransferase, which catalyzes the transfer of geranylgeranyl groups to target proteins, a process known as protein prenylation. This modification is crucial for the proper localization and function of these proteins within the cell. By attaching geranylgeranyl groups to specific proteins, geranylgeranylpyrophosphate plays a role in regulating processes such as cell growth, differentiation, and intracellular signaling. Its function in protein prenylation contributes to the overall regulation of cellular processes and is essential for the proper functioning of various signaling pathways. In this way, geranylgeranylpyrophosphate plays a specific and important role in the molecular mechanisms that govern cellular function and regulation.
Geranylgeranylpyrophosphate triammonium salt (CAS 6699-20-3) References
- Rab geranylgeranyl transferase. A multisubunit enzyme that prenylates GTP-binding proteins terminating in Cys-X-Cys or Cys-Cys. | Seabra, MC., et al. 1992. J Biol Chem. 267: 14497-503. PMID: 1321151
- 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors attenuate beta-amyloid-induced microglial inflammatory responses. | Cordle, A. and Landreth, G. 2005. J Neurosci. 25: 299-307. PMID: 15647473
- Mechanisms of statin-mediated inhibition of small G-protein function. | Cordle, A., et al. 2005. J Biol Chem. 280: 34202-9. PMID: 16085653
- Statins reduce amyloid-beta production through inhibition of protein isoprenylation. | Ostrowski, SM., et al. 2007. J Biol Chem. 282: 26832-26844. PMID: 17646164
- Activation of liver X receptors prevents statin-induced death of 3T3-L1 preadipocytes. | Madsen, L., et al. 2008. J Biol Chem. 283: 22723-36. PMID: 18487205
- Unusual ent-atisane type diterpenoids with 2-oxopropyl skeleton from the roots of Euphorbia ebracteolata and their antiviral activity against human rhinovirus 3 and enterovirus 71. | Wang, B., et al. 2018. Bioorg Chem. 81: 234-240. PMID: 30153588
- Mevalonate biosynthesis pathway regulates the development and survival of brown adipocytes. | Kwon, J., et al. 2023. iScience. 26: 106161. PMID: 36895651
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Geranylgeranylpyrophosphate triammonium salt, 200 µg | sc-200849 | 200 µg | $120.00 |