ABTB2 Inhibitors
ABTB2 inhibitors encompass a range of chemical compounds that interact with various signaling pathways to indirectly inhibit the functional activity of the ABTB2 protein. These inhibitors are not necessarily specific to ABTB2 itself but work by altering the cellular signaling contexts that ABTB2 is part of or responds to. For instance, LY294002 and Wortmannin target the PI3K/Akt pathway, a pivotal signaling cascade in which ABTB2 has a regulatory role. The inhibition of PI3K leads to decreased Akt activation, which in turn could reduce the phosphorylation and negative regulation by ABTB2, effectively inhibiting its function. Similarly, the mTOR pathway inhibitor Rapamycin can also impact ABTB2 activity indirectly due to the close interplay between mTOR signaling and the PI3K/Akt pathway.
On another front, compounds such as SB203580, PD98059, and U0126 work by modulating the MAPK signaling pathways. ABTB2, which is influenced by cellular stress responses, could see its activity altered by the inhibition of p38 MAPK, MEK, and ERK signaling. SB203580, for example, inhibits p38 MAPK,which could reduce the activation of proteins that respond to stress signals, including ABTB2. The JNK pathway, targeted by SP600125, is another stress response pathway potentially relevant to ABTB2's function. Inhibiting JNK could, therefore, lead to a decrease in ABTB2 activity as the cell's stress response is dampened. Additionally, the ROCK inhibitor Y-27632 may impact ABTB2 by altering the actin cytoskeleton dynamics and associated signaling, indicative of the multifaceted ways in which cellular pathways intersect with ABTB2 regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A specific inhibitor of PI3K/Akt pathway. ABTB2 is known to be involved in the negative regulation of this pathway. LY294002 inhibits PI3K, thereby preventing Akt activation. With Akt inhibited, the downstream inhibitory effects on proteins like ABTB2 are reduced, leading to its functional inhibition. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
A p38 MAPK inhibitor. ABTB2's activity is influenced by stress-activated protein kinase pathways like p38 MAPK. By inhibiting p38, SB203580 prevents the phosphorylation and activation of downstream substrates, which in turn can inhibit the functional activity of ABTB2 due to reduced stress signaling. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
A MEK inhibitor which blocks the MAPK/ERK pathway. The MAPK/ERK pathway can regulate a variety of proteins including ABTB2. Inhibition of MEK by PD98059 leads to reduced ERK activation, which can result in decreased regulation of ABTB2 activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Another PI3K inhibitor like LY294002, wortmannin binds irreversibly to PI3K, preventing Akt activation. The consequential decrease in PI3K/Akt signaling can lead to the indirect inhibition of ABTB2 function, as ABTB2 is involved in this pathway. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor which can affect the PI3K/Akt pathway. Since ABTB2 is linked to this pathway, rapamycin's inhibition of mTOR can diminish the functional activity of ABTB2 as part of the downstream effect. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of c-Jun N-terminal kinase (JNK), which is involved in cellular stress responses. By inhibiting JNK, SP600125 can affect proteins regulated by stress response, including potentially ABTB2. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
An inhibitor of MEK1/2, which prevents the activation of the MAPK/ERK pathway. This inhibition can decrease the functional activity of proteins like ABTB2 that are regulated by this pathway. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
A Src family kinase inhibitor. Src kinases can influence a variety of cellular pathways, including those that regulate proteins like ABTB2. Inhibition of Src by PP2 can reduce ABTB2 activity. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
A ROCK inhibitor that can influence the actin cytoskeleton and related signaling pathways. Since ABTB2 is involved in such pathways, the inhibition of ROCK by Y-27632 can lead to a decrease in ABTB2 activity. | ||||||
PD173074 | 219580-11-7 | sc-202610 sc-202610A sc-202610B | 1 mg 5 mg 50 mg | $47.00 $143.00 $680.00 | 16 | |
A FGFR inhibitor. While primarily affecting growth factors, inhibition of FGFR can also influence downstream proteins such as ABTB2 through complex signaling networks. | ||||||