ABHD12B Activators
ABHD12B activators function through various biochemical mechanisms to enhance the activity of this hydrolase enzyme. Activation can occur through modification of intracellular second messenger levels, as seen with compounds that increase cyclic AMP (cAMP) within the cell. Elevated cAMP levels can result in the activation of protein kinases that phosphorylate ABHD12B, leading to enhanced enzyme functionality. Such phosphorylation events are central in the regulation of ABHD12B, as they can alter its conformation and consequently its activity. Additionally, bioactive lipids play a significant role by interacting with receptors that initiate signaling cascades, culminating in the phosphorylation or allosteric modulation of ABHD12B. These lipids may also be metabolized into molecules that directly influence ABHD12B's activation state. Moreover, alterations in intracellular calcium levels can activate calcium-dependent kinases, which can then target ABHD12B for activation through phosphorylation.
Furthermore, the modulation of cellular metabolism and the redox environment by specific cofactors can have an indirect impact on the pathways that lead to ABHD12B activation. For instance, changes in the acylation status of proteins due to the action of sirtuins can affect ABHD12B activity. Similarly, compounds that inhibit protein tyrosine phosphatases or glycogen synthase kinase-3 (GSK-3) can lead to an increase in phosphorylated proteins, creating a favorable environment for the activation of ABHD12B.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
This diterpene activates adenylate cyclase, increasing cAMP levels within cells. Elevated cAMP may enhance ABHD12B activity by promoting phosphorylation events that lead to its activation. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
A non-specific inhibitor of phosphodiesterases, it prevents cAMP degradation, potentially augmenting phosphorylation processes that could activate ABHD12B. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A calcium ionophore that increases intracellular calcium concentration, which could activate calcium-dependent kinases that phosphorylate ABHD12B, enhancing its activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
A potent activator of protein kinase C (PKC) which may phosphorylate ABHD12B directly or influence downstream signaling pathways leading to its activation. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $90.00 $235.00 $4243.00 | 9 | |
This fatty acid can be converted into active lipid signaling molecules that modulate various signaling pathways, potentially influencing ABHD12B activation. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
A bioactive lipid that, through its receptors, can activate signaling pathways leading to phosphorylation events that may enhance ABHD12B activity. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $56.00 $186.00 $296.00 $655.00 $2550.00 $3500.00 $10500.00 | 4 | |
As a cofactor in redox reactions, it may alter cellular metabolism and redox status, indirectly influencing signaling pathways that activate ABHD12B. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
This polyphenol activates sirtuins which may modulate the activity of ABHD12B by influencing acylation status and cellular metabolism. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
A compound that modulates various signaling pathways including NF-κB, which may have downstream effects leading to the activation of ABHD12B. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $45.00 $56.00 $183.00 | 142 | |
An inhibitor of protein tyrosine phosphatases, which can increase tyrosine phosphorylation levels, potentially leading to enhanced activation of ABHD12B. | ||||||