ABCE1 Activators
ABCE1 Activators comprise a selection of chemical compounds that indirectly elevate the functional activity of ABCE1 by modulating various signaling pathways that converge or interact with the biological processes ABCE1 is known to be involved in. The activation cascade initiated by Forskolin, Rolipram, IBMX, and Cilostazol, through their inhibition of distinct phosphodiesterases, leads to a surge in cAMP levels, which subsequently activates PKA. The activation of PKA is pivotal, as it phosphorylates substrates within ABCE1-associated pathways, thereby indirectly enhancing ABCE1 activity. This enhancement is further supplemented by PMA, which triggers PKC, and A23187, which, by elevating intracellular calcium levels, could affect calcium-dependent kinases and proteins that interact with or influence ABCE1's function. These mechanisms, though indirect, contribute to the upregulation of ABCE1's activity without altering its expression levels.
In a complementary manner, the actions of Sildenafil and Tadalafil result in increased cGMP levels, instigating the activation of PKG, which can then target proteins in ABCE1-related signaling pathways, indirectly enhancing ABCE1 activity. Similarly, Y-27632's inhibition of ROCK may alter cytoskeletal dynamics to affect cellular processes where ABCE1 is active. The GSK-3 inhibitor SB 216763 could potentially modulate Wnt signaling pathways, thus influencing the cellular context in which ABCE1 operates. Additionally, ZM 336372's inhibition of c-Raf kinase and the consequent effects on the MAPK/ERK pathway may indirectly promote ABCE1's functional activity. Lastly, LY294002's inhibition of PI3K alters the PI3K/Akt signaling, which can lead to changes in protein activity within ABCE1-related pathways, further contributing to the protein's enhanced functionality. Collectively, these activators function through targeted biochemical interventions to potentiate the activity of ABCE1, delineating a landscape of indirect yet specific enhancement of its role within cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin indirectly enhances ABCE1 function by elevating cAMP levels, which in turn activates protein kinase A (PKA). PKA can phosphorylate various substrates, including those involved in the same cellular processes as ABCE1, thereby enhancing its activity. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram, a selective phosphodiesterase-4 inhibitor, increases intracellular cAMP levels, similarly to Forskolin, promoting PKA activation. This can enhance ABCE1 activity indirectly by phosphorylating proteins within the same pathway. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Isobutylmethylxanthine (IBMX) inhibits phosphodiesterases, leading to increased cAMP levels and subsequently enhancing PKA activity. PKA can then positively influence the functional activity of ABCE1 by phosphorylating proteins in the associated pathways. | ||||||
Cilostazol | 73963-72-1 | sc-201182 sc-201182A | 10 mg 50 mg | $107.00 $316.00 | 3 | |
Cilostazol, a phosphodiesterase 3 inhibitor, leads to increased cAMP levels, resulting in the activation of PKA, which can then indirectly enhance the activity of ABCE1 by acting on related signaling proteins. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that can increase intracellular calcium levels, potentially affecting calcium-dependent protein kinases which can phosphorylate substrates that influence ABCE1 activity indirectly. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate proteins within the same pathways as ABCE1, thus potentially leading to an indirect enhancement of ABCE1 activity through these shared pathways. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a Rho-associated protein kinase (ROCK) inhibitor which may lead to changes in the cytoskeletal arrangement and affect cellular processes that ABCE1 is involved in, thereby indirectly enhancing its activity. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $70.00 $198.00 | 18 | |
SB 216763 is a glycogen synthase kinase-3 (GSK-3) inhibitor which can affect Wnt signaling, potentially altering the cellular environment in a way that enhances the functional activity of ABCE1 indirectly. | ||||||
ZM 336372 | 208260-29-1 | sc-202857 | 1 mg | $46.00 | 2 | |
ZM 336372 is a potent inhibitor of c-Raf kinase, which can influence the MAPK/ERK pathway. This may result in changes to protein activity within this pathway that could indirectly enhance the functional activity of ABCE1. | ||||||
Tadalafil | 171596-29-5 | sc-208412 | 50 mg | $176.00 | 13 | |
Tadalafil, like Sildenafil, is a phosphodiesterase 5 inhibitor and increases cGMP levels, leading to activation of PKG. PKG can then enhance the activity of proteins within ABCE1-related pathways. | ||||||