AATM Activators
AATM activators belong to a distinctive chemical class characterized by their unique ability to modulate specific cellular pathways and processes in various organisms. The term AATM stands for Allosteric Activator of Transcriptional Machinery, indicating their role in regulating gene expression at the transcriptional level. These compounds are known for their molecular interactions with transcriptional machinery components, particularly transcription factors and RNA polymerases. AATM activators act as allosteric effectors, binding to specific sites on these macromolecules and inducing conformational changes that enhance their activity.
Chemically, AATM activators can encompass a diverse range of organic molecules, including small organic compounds, peptides, or even larger macromolecules. Their commonality lies in their ability to interact with transcriptional machinery elements in a manner that leads to increased transcription of target genes. This may involve stabilizing transcription factor-DNA interactions, promoting RNA polymerase recruitment, or facilitating the assembly of transcriptional complexes.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Citric Acid, Anhydrous | 77-92-9 | sc-211113 sc-211113A sc-211113B sc-211113C sc-211113D | 500 g 1 kg 5 kg 10 kg 25 kg | $49.00 $108.00 $142.00 $243.00 $586.00 | 1 | |
Citrate, a key intermediate in the citric acid cycle, can modulate enzyme activities within this cycle. Its abundance or fluctuations directly influence enzymes like GOT2, which links amino acid metabolism with the citric acid cycle. | ||||||
α-Ketoglutaric Acid | 328-50-7 | sc-208504 sc-208504A sc-208504B sc-208504C sc-208504D sc-208504E sc-208504F | 25 g 100 g 250 g 500 g 1 kg 5 kg 16 kg | $32.00 $42.00 $62.00 $108.00 $184.00 $724.00 $2050.00 | 2 | |
Alpha-ketoglutarate, another component of the citric acid cycle, plays a crucial role in amino acid metabolism. Its interaction with enzymes like GOT2 is essential for the balance between carbon and nitrogen metabolism. | ||||||
Oxaloacetic Acid | 328-42-7 | sc-279934 sc-279934A sc-279934B | 25 g 100 g 1 kg | $300.00 $944.00 $7824.00 | 1 | |
Oxaloacetate, a significant metabolite in the citric acid cycle, is also involved in amino acid synthesis and degradation. Its levels can influence GOT2 activity, as it is directly involved in transamination reactions. | ||||||
L-Aspartic acid | 56-84-8 | sc-472377A sc-472377 sc-472377B | 25 g 100 g 500 g | $39.00 $32.00 $47.00 | ||
Aspartate, an amino acid, participates in transamination reactions with GOT2, linking nitrogen metabolism with the citric acid cycle. | ||||||
L-Glutamic Acid | 56-86-0 | sc-394004 sc-394004A | 10 g 100 g | $291.00 $566.00 | ||
Glutamate plays a pivotal role in amino acid metabolism and can interact with GOT2 in transamination processes, affecting both amino acid and citric acid cycle dynamics. | ||||||
Pyruvic acid | 127-17-3 | sc-208191 sc-208191A | 25 g 100 g | $40.00 $94.00 | ||
Pyruvate, a key metabolite in glycolysis, can influence GOT2 activity indirectly by affecting the levels of other citric acid cycle intermediates. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $56.00 $186.00 $296.00 $655.00 $2550.00 $3500.00 $10500.00 | 4 | |
NAD+, as a cofactor, is essential for many enzymatic reactions, including those involving GOT2, influencing its activity indirectly through redox reactions. | ||||||
Coenzyme A | 85-61-0 anhydrous | sc-211123 sc-211123A sc-211123B sc-211123C | 10 mg 25 mg 100 mg 250 mg | $70.00 $116.00 $410.00 $785.00 | 1 | |
Coenzyme A is vital for acyl group transfer and is involved in the citric acid cycle, affecting GOT2 indirectly by modulating the availability of cycle intermediates. | ||||||
Succinic acid | 110-15-6 | sc-212961B sc-212961 sc-212961A | 25 g 500 g 1 kg | $44.00 $74.00 $130.00 | ||
Succinate, a component of the citric acid cycle, can indirectly influence GOT2 activity by altering the cycle's dynamics and availability of intermediates. | ||||||
Fumaric acid | 110-17-8 | sc-250031 sc-250031A sc-250031B sc-250031C | 25 g 100 g 500 g 2.5 kg | $42.00 $56.00 $112.00 $224.00 | ||
Fumarate is involved in the citric acid cycle and can impact GOT2 activity by affecting the balance of cycle intermediates. | ||||||