AATM Antibody (E-7): sc-271702

AATM Antibody (E-7) is a mouse monoclonal IgG2b kappa light chain antibody that detects AATM protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). AATM (E-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Aspartate aminotransferase (AAT) is a crucial enzyme that exists in two isoforms: mitochondrial (AATM) and cytosolic (AATC). AATM plays a vital role in amino acid metabolism and the urea and tricarboxylic acid cycles by catalyzing the conversion of L-aspartate and 2-oxoglutarate into oxaloacetate and L-glutamate. This enzymatic activity is essential for maintaining nitrogen balance and energy production within cells. AATM is predominantly expressed in the liver, where AATM accounts for approximately 80% of the enzyme′s activity, highlighting AATM′s significance in hepatic function. The structural similarity between AATM and AATC, despite their different expression patterns and folding rates, underscores the evolutionary conservation of their functions, while their distinct affinities for molecular chaperones, such as GroEL, may influence their stability and activity in various cellular contexts.

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AATM Antibody (E-7) References:

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4. Incompatibility between mitochondrial and nuclear genomes during oogenesis results in ovarian failure and embryonic lethality.  |  Zhang, C., et al. 2017. Development. 144: 2490-2503. PMID: 28576772
5. Amelioration of Alpha-1 Antitrypsin Deficiency Diseases with Genome Editing in Transgenic Mice.  |  Shen, S., et al. 2018. Hum Gene Ther. 29: 861-873. PMID: 29641323
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7. [Impact of COVID-19 pandemic on information management and adherence to replacement therapy with AAT of patients with alpha-1 antitrypsin deficiency (AATM)].  |  Köhnlein, T., et al. 2022. Pneumologie. 76: 494-498. PMID: 35724679
8. Effect of replacing a portion of inorganic chloride trace minerals with trace mineral amino acid complexes.  |  Kerwin, AL., et al. 2023. J Dairy Sci. 106: 6128-6145. PMID: 37479575
9. The Role of Mental Health Conditions in Early Detection and Treatment of Veterans With Alzheimer's Dementia.  |  O'Connor, MK., et al. 2024. Mil Med. 189: 1409-1413. PMID: 38668648
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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-AATM Antibody (E-7) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-AATM Antibody (E-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

AATM Antibody (E-7) Specifications

Alternate Product Name: AATM

Product Clone Name: E-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 141-211

Epitope Target: AATM

Epitope Species: human

Product Reactivity/Detection: AATM

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for AATM Antibody (E-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin