AATC activators are a specialized group of compounds that modulate the activity of the AATC protein. The designation "AATC" suggests a specificity to a particular protein, but without widely recognized scientific literature detailing the functions and characteristics of a protein by this exact abbreviation, the detailed mechanisms by which these activators work would be speculative. However, speaking generally about protein activators, these molecules can engage with their target proteins in several ways to enhance their biological activity.
Activators often bind to regions of the protein that are separate from the active site, known as allosteric sites, inducing a conformational change that increases the protein's activity. This could mean improving the protein's ability to bind to substrates, enhancing the rate at which it catalyzes reactions, or stabilizing the protein in an active form. Some activators work by blocking inhibitory interactions, thereby preventing the downregulation of protein activity. Others may mimic or boost the effect of natural ligands or cofactors that are essential for the protein's activity. Understanding the function of the AATC protein is vital for grasping how AATC activators could exert their effects. If AATC is involved in a specific signaling pathway, activators might increase the pathway's overall activity, which could have various downstream effects depending on the pathway's role within the cell. For example, if the AATC protein is part of a pathway that regulates cell growth, activators might lead to an increase in cellular proliferation. In a research context, AATC activators would be valuable tools to probe the biological role of AATC, to dissect the signaling pathways it participates in, and to uncover the broader implications of its activity within the cell.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an activator of adenylate cyclase, which increases cAMP levels and subsequently activates protein kinase A (PKA). AATC is known to be phosphorylated by PKA, leading to its activation. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin activates the PI3K/AKT pathway, which can lead to the activation of mTOR. Given that mTOR can phosphorylate and activate AATC, insulin can indirectly activate AATC. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor. Although it is an inhibitor, in certain contexts, the inhibition of mTOR can lead to a feedback activation of the PI3K/AKT pathway, which can then activate AATC. | ||||||
Metformin-d6, Hydrochloride | 1185166-01-1 | sc-218701 sc-218701A sc-218701B | 1 mg 5 mg 10 mg | $292.00 $822.00 $1540.00 | 1 | |
Metformin activates the AMPK pathway, which can lead to the inhibition of mTOR. Similar to rapamycin, this may lead to a feedback activation of the PI3K/AKT pathway, activating AATC. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin activates the NRF2 pathway, which can lead to the upregulation of antioxidant enzymes, including AATC. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates the SIRT1 pathway, which can lead to the activation of PGC-1α. PGC-1α can upregulate the expression of AATC, leading to its activation. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin activates the TRPV1 pathway. Activation of this pathway can lead to increases in intracellular calcium, which can activate calmodulin. Calmodulin can activate AATC. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine activates the AMPK pathway, which leads to a decrease in mTOR activity. This can result in a feedback activation of the PI3K/AKT pathway, which can activate AATC. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin activates the PKA pathway, which can lead to the phosphorylation and activation of AATC. | ||||||
Pyrroloquinoline quinone | 72909-34-3 | sc-210178 | 1 mg | $243.00 | ||
PQQ can activate the SIRT1/PGC-1α pathway. Activation of this pathway can upregulate the expression of AATC, leading to its activation. | ||||||