9430069J07Rik Inhibitors
Chemical inhibitors of APC membrane recruitment 3 function primarily by disrupting the Wnt/β-catenin signaling pathway, which is crucial for the regulation of cell growth and development. NSC 66811 and XAV-939 work by stabilizing Axin levels, a key component of the β-catenin destruction complex. NSC 66811 directly stabilizes Axin, leading to enhanced β-catenin degradation, while XAV-939 inhibits tankyrase enzymes, which in turn prevents Axin degradation. JW55 operates similarly to XAV-939 by antagonizing the PARP domain of tankyrase enzymes, thereby stabilizing Axin and suppressing β-catenin-mediated transcription. IWR-1 also promotes the degradation of β-catenin by stabilizing the Axin destruction complex, thus indirectly inhibiting APC membrane recruitment 3.
The compounds IWP-2 and LGK-974 take a different approach by targeting porcupine, an enzyme required for the post-translational modification and secretion of Wnt proteins. By inhibiting porcupine, these chemicals reduce Wnt ligand availability, leading to diminished activation of the Wnt/β-catenin pathway and a consequent inhibition of APC membrane recruitment 3. PNU-74654, FH535, and KY1220 disrupt the interaction between β-catenin and TCF transcription factors, which is a downstream effect in the Wnt pathway, thereby inhibiting the transcriptional activity of β-catenin and reducing the functionality of APC membrane recruitment 3. PKF118-310 similarly inhibits the interaction between β-catenin and TCF, curtailing the transcriptional activation of Wnt target genes. CGP049090 acts as a small molecule inhibitor, enhancing the degradation of β-catenin and curtailing the function of APC membrane recruitment 3. Lastly, WIKI4 suppresses Wnt signaling by inhibiting tankyrase, which leads to the stabilization of Axin and the subsequent degradation of β-catenin, thereby inhibiting the activity of APC membrane recruitment 3 within this pathway. Each of these chemicals, through their unique mechanisms, effectively inhibits the function of APC membrane recruitment 3 by destabilizing or preventing the accumulation of β-catenin, a central player in the Wnt/β-catenin signaling cascade.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
NSC 66811 | 6964-62-1 | sc-311507 sc-311507A | 10 mg 50 mg | $162.00 $683.00 | ||
NSC 66811 inhibits the Wnt/β-catenin pathway by stabilizing Axin levels, which promotes β-catenin degradation and can lead to the functional inhibition of APC membrane recruitment 3 involved in this pathway. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $36.00 $117.00 $525.00 | 26 | |
XAV-939 inhibits tankyrase 1 and 2, leading to the stabilization of Axin and the inhibition of the Wnt/β-catenin signaling. This results in decreased β-catenin-mediated transcription, which inhibits the activity of APC membrane recruitment 3 that operates downstream in the Wnt pathway. | ||||||
JW 55 | 664993-53-7 | sc-364517 sc-364517A | 10 mg 50 mg | $172.00 $726.00 | ||
JW55 acts as an antagonist of the Wnt/β-catenin pathway by inhibiting the PARP domain of tankyrase 1 and 2, which stabilizes Axin and inhibits β-catenin mediated transcription, thus inhibiting the functional role of APC membrane recruitment 3 in this pathway. | ||||||
IWR-1-endo | 1127442-82-3 | sc-295215 sc-295215A | 5 mg 10 mg | $82.00 $135.00 | 19 | |
IWR-1 inhibits Wnt response by stabilizing the Axin destruction complex, which leads to the degradation of β-catenin and inhibits APC membrane recruitment 3 activity, which is associated with the β-catenin destruction complex. | ||||||
IWP-2 | 686770-61-6 | sc-252928 sc-252928A | 5 mg 25 mg | $96.00 $292.00 | 27 | |
IWP-2 inhibits Wnt production by blocking porcupine, which is required for Wnt ligand acylation and secretion, this reduction in Wnt ligands inhibits activation of APC membrane recruitment 3 associated with the Wnt/β-catenin pathway. | ||||||
LGK 974 | 1243244-14-5 | sc-489380 sc-489380A | 5 mg 50 mg | $359.00 $1295.00 | 2 | |
LGK-974 is a porcupine inhibitor, which prevents the secretion and activity of Wnt proteins, leading to the inhibition of Wnt/β-catenin signaling and consequently inhibiting the function of APC membrane recruitment 3 in this pathway. | ||||||
PNU-74654 | 113906-27-7 | sc-258020 sc-258020A | 5 mg 25 mg | $131.00 $495.00 | 7 | |
PNU-74654 disrupts the interaction between β-catenin and TCF, inhibiting β-catenin/TCF mediated transcription. This disruption leads to the inhibition of APC membrane recruitment 3 which is involved in the formation of the β-catenin destruction complex. | ||||||
β-Catenin/Tcf Inhibitor, FH535 | 108409-83-2 | sc-221398 sc-221398A | 10 mg 50 mg | $182.00 $374.00 | 7 | |
FH535 is a dual inhibitor of β-catenin and peroxisome proliferator-activated receptor (PPAR), leading to the downregulation of Wnt/β-catenin signaling and the inhibition of APC membrane recruitment 3 activity within this pathway. | ||||||
PKF118-310 | 84-82-2 | sc-364590 sc-364590A | 5 mg 25 mg | $180.00 $651.00 | ||
PKF118-310 inhibits the binding of β-catenin to TCF transcription factors, leading to the inhibition of Wnt/β-catenin-dependent transcription and the functional activity of APC membrane recruitment 3 in the Wnt/β-catenin pathway. | ||||||
WIKI4 | 838818-26-1 | sc-397021 sc-397021A | 5 mg 25 mg | $90.00 $351.00 | ||
WIKI4 inhibits the Wnt/β-catenin signaling pathway by acting on the tankyrase domain, leading to Axin stabilization, β-catenin degradation, and inhibition of APC membrane recruitment 3 involved in β-catenin regulation. | ||||||