WIKI4 CAS: 838818-26-1
MF: C29H23N5O3S
MW: 521.59
A potent inhibitor of Wnt/β-catenin signaling.

WIKI4 (CAS 838818-26-1)

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Synonym: 2-[3-[[4-(4-Methoxyphenyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]propyl]-1H-benz[de]isoquinoline-1,3(2H)-dione
Application: A potent inhibitor of Wnt/β-catenin signaling
CAS Number: 838818-26-1
Molecular Weight: 521.59
Molecular Formula: C29H23N5O3S
* Refer to Certificate of Analysis for lot specific data (including water content).

WIKI4 is a potent inhibitor of Wnt/β-catenin signaling with an EC50 ~ 75 nM in all cell lines tested including DLD1 colorectal cancer cells, NALM6 B cells, U2OS osteosarcoma cells, and hESCs. WIKI4 inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) with an IC50 of 15 nM, preventing the ubiquitination and degradation of axin and thereby antagonizing Wnt signalling.

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/ml, clear, warmed).
Storage :
Store at -20° C
Boiling Point :
~783.1 °C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.72 (Predicted)
IC50 :
auto-ADP-ribosylation of tankyrase 2 (TNKS2): IC50 = 15 nM; Wnt/β-catenin signaling: EC5050 = ~75 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
2984337
SMILES :
COC1=CC=C(C=C1)N2C(=NN=C2SCCCN3C(=O)C4=CC=CC5=C4C(=CC=C5)C3=O)C6=CC=NC=C6

Download SDS (MSDS)

Certificate of Analysis

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