Molecular structure of NSC 66811, CAS Number: 6964-62-1
NSC 66811 (CAS 6964-62-1)
Alternate Names:
MDM2 Antagonist II; MDM2 Inhibitor II
CAS Number:
6964-62-1
Molecular Weight:
340.42
Molecular Formula:
C23H20N2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Potent MDM2 inhibitor (Ki = 120 nM) which disrupts MDM2-p53 interaction and activates p53 function. Induces p21, p53 and MDM2 accumulation in human colon cancer cells in vitro.
NSC 66811 (CAS 6964-62-1) References
- Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy. | Lu, Y., et al. 2006. J Med Chem. 49: 3759-62. PMID: 16789731
- Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy. | Shangary, S. and Wang, S. 2009. Annu Rev Pharmacol Toxicol. 49: 223-41. PMID: 18834305
- A comparative analysis of the ubiquitination kinetics of multiple degrons to identify an ideal targeting sequence for a proteasome reporter. | Melvin, AT., et al. 2013. PLoS One. 8: e78082. PMID: 24205101
- Modulation of the pentose phosphate pathway alters phase I metabolism of testosterone and dextromethorphan in HepG2 cells. | Xiao, WJ., et al. 2015. Acta Pharmacol Sin. 36: 259-67. PMID: 25619394
- Inhibitors of ubiquitin E3 ligase as potential new antimalarial drug leads. | Jain, J., et al. 2017. BMC Pharmacol Toxicol. 18: 40. PMID: 28577368
- Influenza A viruses alter the stability and antiviral contribution of host E3-ubiquitin ligase Mdm2 during the time-course of infection. | Pizzorno, A., et al. 2018. Sci Rep. 8: 3746. PMID: 29487367
- Small-molecule MDM2/X inhibitors and PROTAC degraders for cancer therapy: advances and perspectives. | Fang, Y., et al. 2020. Acta Pharm Sin B. 10: 1253-1278. PMID: 32874827
- Screening of a Focused Ubiquitin-Proteasome Pathway Inhibitor Library Identifies Small Molecules as Novel Modulators of Botulinum Neurotoxin Type A Toxicity. | Sen, E., et al. 2021. Front Pharmacol. 12: 763950. PMID: 34646144
Inhibitor of:
α Enolase, 9430069J07Rik, MDM2, p53AIP1, Rad9B, Tom1, Trp53i11, and TRUNDD.Activator of:
cyclin J, p53, UBE2Q2, and WDR5.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NSC 66811, 10 mg | sc-311507 | 10 mg | $159.00 | |||
NSC 66811, 50 mg | sc-311507A | 50 mg | $670.00 |