8-oxoG DNA Lesion Inhibitors
Chemical Class Description: The class of 8-oxoG DNA lesion inhibitors consists of compounds that indirectly modulate the formation and repair of 8-oxoG lesions by targeting oxidative stress and DNA repair mechanisms. These compounds, while not interacting directly with 8-oxoG, influence the cellular antioxidant capacity and DNA repair pathways. Antioxidants like N-Acetylcysteine, Vitamin C, Vitamin E, Curcumin, Resveratrol, Quercetin, Lycopene, Silymarin, Green Tea Extract, and Melatonin can reduce the levels of oxidative stress in cells, limiting the formation of oxidative DNA lesions like 8-oxoG.
Minerals like Zinc and Selenium, essential for numerous biological processes, play crucial roles in enhancing the body's antioxidant defenses and facilitating DNA repair mechanisms. Zinc is known for its role in various enzymatic reactions, including those in DNA repair pathways, while Selenium is a component of antioxidant enzymes like glutathione peroxidase. The use of these compounds can be a strategic approach to reducing oxidative stress and enhancing DNA repair, thereby indirectly limiting the formation and persistence of 8-oxoG lesions, a common form of oxidative DNA damage.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
Antioxidant that replenishes glutathione levels, potentially reducing oxidative DNA damage like 8-oxoG. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $46.00 | 5 | |
Antioxidant, can reduce oxidative stress, potentially limiting 8-oxoG formation. | ||||||
(+)-α-Tocopherol | 59-02-9 | sc-214454 sc-214454A sc-214454B sc-214454C | 10 g 25 g 100 g 1 kg | $43.00 $62.00 $141.00 $430.00 | ||
Lipid-soluble antioxidant, protects cell membranes from oxidative damage, potentially reducing 8-oxoG formation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Anti-inflammatory and antioxidant, potentially reduces oxidative stress and 8-oxoG lesions. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Antioxidant, can modulate cellular oxidative stress, potentially limiting 8-oxoG formation. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Flavonoid with antioxidant properties, may reduce oxidative DNA damage including 8-oxoG. | ||||||
Lycopene | 502-65-8 | sc-205738 sc-205738A sc-205738B | 1 mg 5 mg 1 g | $146.00 $582.00 $6248.00 | 4 | |
Antioxidant found in tomatoes, potentially limits oxidative damage to DNA. | ||||||
Silymarin group, mixture of isomers | 65666-07-1 | sc-301806 | 50 g | $325.00 | ||
Antioxidant, may protect against oxidative stress and consequent DNA damage. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Strong antioxidant, may limit oxidative DNA damage including 8-oxoG. | ||||||
Melatonin | 73-31-4 | sc-207848 sc-207848A sc-207848B sc-207848C sc-207848D sc-207848E | 1 g 5 g 25 g 100 g 250 g 1 kg | $65.00 $73.00 $218.00 $697.00 $1196.00 $3574.00 | 16 | |
Antioxidant, can reduce oxidative stress, potentially limiting 8-oxoG formation. | ||||||