8-oxoG DNA Lesion Antibody (483.15): sc-130914

8-oxoG DNA Lesion Antibody (483.15) is a mouse monoclonal IgM antibody that detects the 8-oxoG DNA Lesion protein in non-species reactive applications such as immunofluorescence (IF) and enzyme-linked immunosorbent assay (ELISA). Anti-8-oxoG DNA Lesion antibody (483.15) is available as a non-conjugated format, providing researchers with a reliable tool for studying oxidative DNA damage. The 8-oxoG lesion, specifically 8-oxoguanine, is a significant marker of oxidative stress and arises from the oxidation of guanine, one of the four nucleobases in DNA. 8-oxoG presence can lead to mispairing with adenine during DNA replication, resulting in G:C to T:A transversions, ultimately threatening genomic integrity and stability. Recognition and repair of 8-oxoG involves specialized DNA repair enzymes, including 8-oxoguanine DNA glycosylases, which play a vital role in maintaining cellular health and preventing mutations that could lead to diseases such as cancer. Anti-8-oxoG DNA Lesion antibody (483.15) enables researchers to gain insights into DNA repair mechanisms and oxidative damage implications in various biological contexts.

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8-oxoG DNA Lesion Antibody (483.15) References:

1. Multiple DNA glycosylases for repair of 8-oxoguanine and their potential in vivo functions.  |  Hazra, TK., et al. 2001. Prog Nucleic Acid Res Mol Biol. 68: 193-205. PMID: 11554297
2. Repair of 8-oxoguanine and Ogg1-incised apurinic sites in a CHO cell line.  |  Boiteux, S. and le Page, F. 2001. Prog Nucleic Acid Res Mol Biol. 68: 95-105. PMID: 11554315
3. Immunofluorescent detection of 8-oxoguanine DNA lesions in liver cells from aging OXYS rats, a strain prone to overproduction of free radicals.  |  Kemeleva, EA., et al. 2006. Mutat Res. 599: 88-97. PMID: 16574166
4. Different DNA repair strategies to combat the threat from 8-oxoguanine.  |  Russo, MT., et al. 2007. Mutat Res. 614: 69-76. PMID: 16769088
5. Molecular basis of transcriptional mutagenesis at 8-oxoguanine.  |  Damsma, GE. and Cramer, P. 2009. J Biol Chem. 284: 31658-63. PMID: 19758983
6. Measurement of the Oxidative DNA Lesion 8-Oxoguanine (8-oxoG) by ELISA or by High-Performance Liquid Chromatography (HPLC) with Electrochemical Detection.  |  Drake, DM., et al. 2019. Methods Mol Biol. 1965: 313-328. PMID: 31069684
7. HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer's disease.  |  Pao, PC., et al. 2020. Nat Commun. 11: 2484. PMID: 32424276
8. Quantification of 8-oxoG in Plant Telomeres.  |  Castillo-González, C., et al. 2022. Int J Mol Sci. 23: PMID: 35563379
9. Linking oxidative DNA lesion 8-OxoG to tumor development and progression.  |  Zhao, Y., et al. 2022. Yi Chuan. 44: 466-477. PMID: 35729095
10. The Role of 8-oxoG Repair Systems in Tumorigenesis and Cancer Therapy.  |  Li, C., et al. 2022. Cells. 11: PMID: 36497058
11. Single-molecule analysis of DNA-binding proteins from nuclear extracts (SMADNE).  |  Schaich, MA., et al. 2023. Nucleic Acids Res. 51: e39. PMID: 36861323
12. The presence of two distinct 8-oxoguanine repair enzymes in human cells: their potential complementary roles in preventing mutation.  |  Hazra, TK., et al. 1998. Nucleic Acids Res. 26: 5116-22. PMID: 9801308

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-8-oxoG DNA Lesion Antibody (483.15) has 23 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

8-oxoG DNA Lesion Antibody (483.15) Specifications

Alternate Product Name: 8-oxoG DNA Lesion

Product Clone Name: 483.15

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids:

Epitope Target: 8-oxoG DNA Lesion

Epitope Species: human

Product Reactivity/Detection: 8-oxoG Lesions

Species Reactivity/Detection: NSR

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 23 citations in various scientific publications

Available Conjugates/Forms for 8-oxoG DNA Lesion Antibody (483.15): N/A