7530422B04Rik Inhibitors
The classification Dnmt3bos Inhibitors encompasses a broad spectrum of chemical compounds that share the capacity to influence the activity of DNA methyltransferase 3B (DNMT3B). DNMT3B is an enzyme that catalyzes the transfer of methyl groups to cytosine residues in DNA, a key epigenetic modification that can regulate gene expression. Inhibition of this enzyme can lead to changes in the methylation landscape of the genome, which can affect the expression and function of genes and associated non-coding RNAs, such as antisense transcripts like Dnmt3bos.
Compounds such as 5-azacytidine and decitabine are cytidine analogs that, once incorporated into DNA during replication, covalently bind to DNMTs, including DNMT3B. This binding results in the depletion of DNMT activity and a subsequent reduction in DNA methylation. Non-nucleoside compounds like RG108 and SGI-1027 inhibit DNMTs by binding to their active sites, thereby preventing them from methylating DNA. Other compounds, including natural products like EGCG, curcumin, quercetin, and oleuropein, have also been found to exhibit inhibitory effects on DNMTs, though the precise mechanisms may vary and are not fully understood.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A nucleoside analog that incorporates into DNA, inhibits DNMT activity by covalent trapping, and leads to DNA hypomethylation. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
Similar to 5-azacytidine, it integrates into DNA and inhibits DNMTs, reducing DNA methylation levels. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
Non-nucleoside inhibitor that binds to the catalytic domain of DNMTs, preventing the methyl transfer to DNA. | ||||||
SGI-1027 | 1020149-73-8 | sc-473875 | 10 mg | $213.00 | ||
Small molecule that inhibits DNMT activity, possibly by interacting with the active site or the substrate binding site. | ||||||
Zebularine | 3690-10-6 | sc-203315 sc-203315A sc-203315B | 10 mg 25 mg 100 mg | $129.00 $284.00 $1004.00 | 3 | |
A cytidine analog that can be incorporated into DNA and inhibit DNMTs, leading to DNA demethylation. | ||||||
Hydralazine-15N4 Hydrochloride | 304-20-1 (unlabeled) | sc-490605 | 1 mg | $480.00 | ||
Though primarily an antihypertensive agent, it has been observed to inhibit DNA methylation by DNMTs. | ||||||
Procaine | 59-46-1 | sc-296134 sc-296134A sc-296134B sc-296134C | 25 g 50 g 500 g 1 kg | $110.00 $193.00 $407.00 $628.00 | 1 | |
Local anesthetic that has shown DNA methylation inhibition, which can influence DNMT3B's activity. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
An agent used for chronic alcoholism, found to inhibit DNMT and alter methylation status. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Green tea polyphenol that has been reported to inhibit DNMTs, affecting DNA methylation catalyzed by enzymes like DNMT3B. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
A natural phenol found in turmeric, curcumin has shown inhibitory effects on DNMT activity. | ||||||