6720456H20Rik Inhibitors
A chemical class named TMEM260 Inhibitors would encompass compounds that influence the function or expression of the transmembrane protein 260. This could be achieved via direct interaction with the protein or indirectly by modulating the cellular pathways and processes that the protein is involved in. Since TMEM260's exact functions and pathways are not clearly defined, the inhibitors listed do not target TMEM260 specifically but rather engage with general cellular mechanisms that are likely to influence a wide range of transmembrane proteins.
The inhibitors target various aspects of cell biology, such as phosphoinositide signaling (Wortmannin, LY294002), calcium signaling (Cyclosporin A, 2-APB, Thapsigargin), vesicle trafficking (Brefeldin A, Dynasore), protein phosphorylation (Okadaic acid, Genistein, Gö6976), and ion homeostasis (Monensin). Each of these chemicals acts on specific enzymes, channels, or cellular processes that are fundamental to maintaining the structure and function of the cellular membrane and its associated proteins. Through these broad mechanisms, it is likely that the function or expression of TMEM260, like other transmembrane proteins, would be affected.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
A potent inhibitor of phosphoinositide 3-kinases (PI3K), which could affect transmembrane signaling and potentially alter the function or expression of transmembrane proteins. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
An inhibitor of ADP-ribosylation factor (ARF), which modulates vesicle trafficking within cells; could impact the localization and function of transmembrane proteins. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Inhibits the activity of calcineurin leading to altered T-cell activation. It affects calcium ion channels and could indirectly influence transmembrane protein functions. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
A dynamin inhibitor, which impairs endocytosis. This could affect the internalization and recycling of transmembrane proteins. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $27.00 $52.00 | 37 | |
Blocks inositol 1,4,5-trisphosphate (IP3) receptors and store-operated calcium entry (SOCE) which can alter signaling pathways affecting membrane protein activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
Another PI3K inhibitor, which could disrupt signaling cascades that impact transmembrane protein function. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
A potent inhibitor of protein phosphatases 1 and 2A, altering phosphorylation states of cellular proteins, potentially including transmembrane proteins. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Inhibits protein tyrosine kinases which can affect signal transduction pathways related to transmembrane proteins. | ||||||
Gö 6976 | 136194-77-9 | sc-221684 | 500 µg | $223.00 | 8 | |
A selective inhibitor of protein kinase C (PKC), which can modify the activity of proteins involved in cell signaling, including those in the membrane. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
A carboxylic ionophore that alters ion gradients across membranes, possibly affecting transmembrane protein function. | ||||||