6330416G13Rik Activators
RISCR Activators are a collective group of chemical entities that facilitate the augmentation of RISCR's biochemical functions through various indirect mechanisms within cellular signaling networks. For instance, compounds like Forskolin and Epigallocatechin gallate (EGCG) serve to enhance RISCR activity by modulating secondary messenger systems and kinase activity, respectively. Forskolin increases intracellular cAMP levels, thereby activating PKA, which is known to phosphorylate proteins that can influence RISCR activity. EGCG, on the other hand, inhibits kinases that would otherwise suppress pathways RISCR is involved with, allowing for a more robust activity of RISCR. RISCR Activators encompass a spectrum of chemical compounds that indirectly promote the functional activity of the RISCR protein through discrete intracellular signaling pathways. Forskolin, by elevating cAMP, and Epigallocatechin gallate, by inhibiting certain kinases, both serve to potentiate RISCR's role by enhancing the phosphorylation state of proteins within RISCR's operational pathways or by alleviating inhibitory controls.
Sphingosine-1-phosphate and the PI3K inhibitors LY294002 and Wortmannin are exemplars of compounds that work through lipid signaling and the modulation of the PI3K/AKT pathway, respectively, to indirectly upregulate the activity of RISCR. These agents, by altering the regulatory landscape of RISCR's signaling milieu, facilitate a more conducive environment for RISCR's enhanced function. Further contributing to the operational enhancement of RISCR are the calcium modulators Ionomycin and A23187, both of which increase intracellular calcium levels, thus activating calcium-dependent kinases that could augment RISCR activity. PMA operates through PKC activation, which can lead to the phosphorylation of proteins within RISCR's pathways, while the MEK inhibitor U0126 and the p38 MAPK inhibitor SB203580 shift cellular signaling dynamics in favor of pathways that enhance RISCR's functional state.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate inhibits specific kinases that negatively regulate pathways RISCR is involved in. This inhibition allows RISCR to function more effectively by reducing the inhibitory phosphorylations on the protein or associated signaling molecules. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate acts on its receptors to activate intracellular signaling cascades, such as the PI3K/AKT pathway, that can lead to the activation of downstream targets, thereby indirectly enhancing the activity of RISCR. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, which can activate calmodulin and calcium-dependent kinases, thus potentially enhancing the activation state or functional capacity of RISCR through downstream effects. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate proteins within pathways that RISCR is a part of, leading to an increase in RISCR's functional activity through indirect signaling effects. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can modulate PI3K/AKT pathway activity. By inhibiting PI3K, LY294002 may reduce negative regulatory influences on pathways involving RISCR, thereby enhancing RISCR's functional activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor, which can similarly enhance RISCR activity by reducing the negative feedback on signaling pathways RISCR participates in, ultimately leading to an indirect enhancement of RISCR function. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a MEK inhibitor that can shift signaling dynamics in cells by affecting the MAPK/ERK pathway, potentially increasing the activity of RISCR by altering the phosphorylation state of proteins within RISCR-related pathways. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin inhibits the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) leading to increased cytosolic calcium levels, which may activate calcium-dependent signaling pathways that enhance RISCR activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is another calcium ionophore that increases intracellular calcium, similar to Ionomycin, and can activate signaling pathways that result in the potentiation of RISCR's functional activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor that can alter cellular signaling by inhibiting p38 kinase activity. This may lead to an enhancement of RISCR activity by impacting related proteins and pathways that work in concert with RISCR. | ||||||