6030422M02Rik Inhibitors
The classification of Mcmdc2 Inhibitors refers to compounds that indirectly affect the function of Mcmdc2, a protein involved in DNA replication. Since Mcmdc2 is part of the replication machinery, its activity is tightly linked to the overall process of DNA synthesis. The compounds listed target various stages of DNA replication and repair, which are processes where Mcmdc2 plays a role. Agents such as Aphidicolin and Hydroxyurea interfere with the availability of nucleotides or the activity of DNA polymerases, while nucleoside analogs like Gemcitabine, Fludarabine, Cladribine, and Cytarabine get incorporated into DNA or inhibit synthesis, leading to replication stress. This can impact the function of Mcmdc2, which is necessary for proper DNA replication.
Other compounds, such as 5-Fluorouracil and Thioguanine, introduce metabolic stress by inhibiting thymidylate synthase or incorporating into DNA as false nucleotides, respectively. This can cause DNA damage and replication forks stalling, where Mcmdc2's role is critical. Topoisomerase inhibitors like Etoposide and Camptothecin induce DNA breaks and interfere with the replication process, which can indirectly affect Mcmdc2 function. Mitoxantrone and Actinomycin D, by interfering with DNA replication and repair enzymes or by preventing RNA synthesis, respectively, can also impact the cellular processes that Mcmdc2 is involved in.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $82.00 $300.00 $1082.00 | 30 | |
Inhibits DNA polymerase alpha and can disrupt DNA replication, indirectly affecting Mcmdc2 function in DNA synthesis. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Inhibits ribonucleotide reductase, leading to depletion of deoxyribonucleotides and can impede DNA replication where Mcmdc2 is involved. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
Metabolized into inhibitors of thymidylate synthase, can lead to DNA damage and impact Mcmdc2's role in DNA replication. | ||||||
2′-Deoxy-2′,2′-difluorocytidine | 95058-81-4 | sc-275523 sc-275523A | 1 g 5 g | $56.00 $128.00 | ||
Nucleoside analog that can incorporate into DNA and halt replication, indirectly affecting Mcmdc2 activity. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Inhibits topoisomerase II, leading to DNA damage and can alter DNA replication processes involving Mcmdc2. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Inhibits topoisomerase I and can cause DNA damage, potentially interfering with Mcmdc2's function in DNA replication. | ||||||
Fludarabine | 21679-14-1 | sc-204755 sc-204755A | 5 mg 25 mg | $57.00 $200.00 | 15 | |
Phosphorylated form can incorporate into DNA and disrupt replication, indirectly inhibiting Mcmdc2. | ||||||
Mitoxantrone | 65271-80-9 | sc-207888 | 100 mg | $279.00 | 8 | |
Interfers with DNA replication and repair enzymes, which can disrupt processes involving Mcmdc2. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Intercalates into DNA and prevents RNA synthesis, can also affect DNA replication where Mcmdc2 is involved. | ||||||
6-Thioguanine | 154-42-7 | sc-205587 sc-205587A | 250 mg 500 mg | $41.00 $53.00 | 3 | |
Incorporates into DNA as a false nucleotide, can impede DNA replication mechanisms associated with Mcmdc2. | ||||||