5430411K18Rik Activators
Chemical activators of Epg5 engage the autophagy pathway by various molecular mechanisms that converge on the functional activation of this protein. Rapamycin, by binding to FKBP12, inhibits mTOR, a pivotal control point in autophagy, thus activating autophagic processes that Epg5 mediates. Torin 1, similar to rapamycin, is a selective mTOR inhibitor that activates autophagy, which implicates a role for Epg5 in the enhanced autophagic flux. Perifosine, by inhibiting Akt, leads to reduced mTOR activity and subsequently stimulates autophagy, thereby involving Epg5 in the autophagic tethering and fusion processes. Spermidine, through the inhibition of acetyltransferase EP300, leads to the deacetylation of autophagy-related proteins and the subsequent activation of autophagy, calling upon the functionality of Epg5 for autophagosome formation and maturation.
In addition to these, carbamazepine promotes autophagy by impairing inositol synthesis, which in turn requires the activation of Epg5 for the autophagosome-lysosome fusion process. Lithium stimulates Epg5 by inhibiting inositol monophosphatase, leading to the activation of autophagic pathways. Trehalose, an mTOR-independent autophagy inducer, activates Epg5 by promoting lysosomal clearance of autophagy substrates. Resveratrol activates Epg5 by modulating the AMPK/mTOR/ULK1 pathway, enhancing autophagy. Nicotinamide activates autophagy by inhibiting SIRT1, causing deacetylation of autophagy-related proteins, which involves Epg5 activation. Metformin, through AMPK activation and subsequent mTOR inhibition, activates Epg5 as a necessary component for autophagic vesicle maturation. Lastly, verapamil and 3-Methyladenine modulate autophagy through calcium level regulation and PI3K signaling, respectively, contributing to the functional activation of Epg5 within the autophagic machinery.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin binds to FKBP12 and together, they inhibit mTOR, which is a key regulator of autophagy. By inhibiting mTOR, rapamycin activates autophagic processes, which Epg5 is known to mediate, thereby functionally activating Epg5 by enhancing autophagic flux. | ||||||
Torin 1 | 1222998-36-8 | sc-396760 | 10 mg | $245.00 | 7 | |
Torin 1 is a potent inhibitor of mTOR, more selective than rapamycin. Inhibition of mTOR by Torin 1 robustly activates autophagy. Since Epg5 is an essential component of the autophagy pathway, Torin 1's activation of autophagy will result in the functional activation of Epg5. | ||||||
Perifosine | 157716-52-4 | sc-364571 sc-364571A | 5 mg 10 mg | $188.00 $327.00 | 1 | |
Perifosine activates autophagy by acting on the Akt/mTOR pathway. It inhibits Akt, leading to decreased mTOR activity, thereby promoting autophagy. Through this mechanism, perifosine would facilitate the activation of Epg5 in the process of autophagic tethering and fusion. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $57.00 $607.00 $176.00 | ||
Spermidine induces autophagy via inhibition of the acetyltransferase EP300, which results in the deacetylation of autophagy-related proteins. This process activates autophagy, thereby functionally activating Epg5 as it is required for autophagosome formation and maturation. | ||||||
Carbamazepine | 298-46-4 | sc-202518 sc-202518A | 1 g 5 g | $33.00 $71.00 | 5 | |
Carbamazepine induces autophagy by inhibiting inositol synthesis, which in turn activates the Epg5 pathway as part of the broader autophagic response. As Epg5 is essential for autophagosome-lysosome fusion, its function is activated by carbamazepine’s promotion of the autophagic process. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium promotes autophagy by inhibiting inositol monophosphatase, leading to the activation of autophagic pathways. Epg5, being involved in the autophagic process, is functionally activated as a result of lithium-induced autophagy stimulation. | ||||||
D-(+)-Trehalose Anhydrous | 99-20-7 | sc-294151 sc-294151A sc-294151B | 1 g 25 g 100 g | $30.00 $167.00 $260.00 | 2 | |
Trehalose acts as an mTOR-independent autophagy inducer. It can activate autophagy by enhancing the lysosomal clearance of autophagy substrates. This activation of autophagy would functionally activate Epg5 by engaging it in the autophagic flux. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol can activate autophagy by modulating the AMPK/mTOR/ULK1 pathway. By activating AMPK and inhibiting mTOR, it promotes autophagy and thus the functional activation of Epg5, which is a key autophagy adaptor protein. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
Nicotinamide, a form of vitamin B3, activates autophagy by inhibiting the SIRT1 enzyme, leading to deacetylation changes of autophagy-related proteins. Through this mechanism, Epg5 is functionally activated as part of the autophagic process. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Metformin activates autophagy by activating AMPK, which inhibits the mTOR pathway, a negative regulator of autophagy. This would lead to the functional activation of Epg5, as it is essential for autophagic vesicle maturation. | ||||||