5330437I02Rik Inhibitors

Oacyl inhibitors encompass a range of compounds that indirectly target the enzymatic activity of O-acyltransferase like proteins by modulating the availability of substrates or altering related lipid metabolic pathways. These inhibitors include agents such as Triclosan and Cerulenin, which can disrupt fatty acid synthesis, thereby potentially limiting the availability of acyl groups required for the Oacyl transferase reaction. Compounds like C75, Orlistat, and TOFA may alter lipid metabolism and availability of fatty acids, which are necessary substrates for the Oacyl enzyme's acyl transfer actions.

Moreover, inhibitors such as Tunicamycin and Triacsin C can influence protein glycosylation and acyl-CoA availability, respectively, which are critical for the proper functioning of Oacyl. Thiolactomycin and Soraphen A target key enzymes in fatty acid synthesis, potentially reducing the pool of fatty acids that could be transferred by Oacyl proteins. Betulinic acid and Plumbagin are known to have broad effects on metabolic pathways, which can lead to alterations in the cellular lipid environment, affecting the Oacyl enzyme's activity. Lastly, Simvastatin's role in cholesterol synthesis inhibition can have downstream effects on lipid rafts and membrane composition, which can indirectly modulate the functional environment of Oacyl.