4930547C10Rik Activators
Chemical activators of toporsl include a range of compounds that interact with DNA and DNA-modifying enzymes, eliciting a response that involves the activation of toporsl to facilitate DNA repair. Camptothecin operates by stabilizing the complex formed between DNA and topoisomerase I, resulting in an accumulation of DNA breaks that require toporsl's intervention. Topotecan, similarly, hinders the re-ligation function of topoisomerase I, leading to DNA damage that necessitates toporsl's repair activity. SN-38, the active derivative of irinotecan, also stabilizes the DNA-topoisomerase complex, creating a context in which toporsl's activity is needed.
Additionally, beta-Lapachone induces DNA damage through the generation of reactive oxygen species and the stabilization of topoisomerase I-DNA cleavable complexes, both circumstances that prompt the activation of toporsl. Indotecan and genistein, although through different mechanisms, result in DNA breaks that engage toporsl; indotecan by directly inhibiting topoisomerase I and genistein by inhibiting topoisomerase II, which can lead to aberrant recombination intermediates. Etoposide and teniposide target topoisomerase II, leading to DNA double-strand breaks that necessitate the activation of toporsl for repair. Ellipticine, amsacrine, mitoxantrone, and pixantrone are additional chemicals that intercalate into DNA or inhibit topoisomerase II, resulting in DNA damage that invokes the repair functions of toporsl. Each of these chemical activators, through their interaction with DNA or inhibition of topoisomerases, indirectly promote the activation of toporsl as it is crucial for the cellular process of DNA repair.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Camptothecin stabilizes the Top1-DNA cleavage complex, leading to an increase in the DNA breaks that the topoisomerase I binding, arginine/serine-rich like (toporsl) protein must process, thereby activating its DNA repair function. | ||||||
Topotecan | 123948-87-8 | sc-338718 | 100 mg | $571.00 | ||
Topotecan inhibits the re-ligation activity of topoisomerase I, thereby necessitating increased activation of the toporsl protein to resolve the resulting DNA damage. | ||||||
SN 38 | 86639-52-3 | sc-203697 sc-203697A sc-203697B | 10 mg 50 mg 500 mg | $117.00 $335.00 $883.00 | 19 | |
SN-38, the active metabolite of irinotecan, inhibits topoisomerase I by stabilizing the DNA-topoisomerase complex, which indirectly necessitates enhanced activation of toporsl for DNA damage repair. | ||||||
β-Lapachone | 4707-32-8 | sc-200875 sc-200875A | 5 mg 25 mg | $110.00 $450.00 | 8 | |
Beta-Lapachone induces DNA strand breaks through the generation of reactive oxygen species and topoisomerase I-DNA cleavable complexes, both of which require the activation of toporsl for DNA repair. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, through its role as a topoisomerase II inhibitor, generates DNA breaks and aberrant recombination intermediates, which can activate the toporsl protein as it is recruited to repair these sites of DNA damage. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide targets topoisomerase II, which can cause DNA double-strand breaks that indirectly lead to the activation of toporsl as it engages in DNA repair processes. | ||||||
Teniposide | 29767-20-2 | sc-204910 sc-204910A | 25 mg 100 mg | $72.00 $230.00 | 6 | |
Teniposide inhibits topoisomerase II, similar to etoposide, which can lead to DNA damage that requires the activation of toporsl for resolution. | ||||||
Ellipticine | 519-23-3 | sc-200878 sc-200878A | 10 mg 50 mg | $142.00 $558.00 | 4 | |
Ellipticine intercalates into DNA and inhibits topoisomerase II, leading to DNA damage that necessitates the activation of toporsl for DNA repair. | ||||||
Amsacrine hydrochloride | 54301-15-4 | sc-214540 | 10 mg | $232.00 | ||
Amsacrine, as a topoisomerase II inhibitor, causes DNA cleavage and damage, which activates toporsl as part of the cellular response to repair DNA. | ||||||
Mitoxantrone | 65271-80-9 | sc-207888 | 100 mg | $279.00 | 8 | |
Mitoxantrone is an anthracenedione that intercalates into DNA and inhibits topoisomerase II, causing DNA damage that requires the activation of toporsl for repair. | ||||||