Date published: 2025-12-19

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4930547C10Rik Inhibitors

The chemical class broadly termed as Toporsl Inhibitors refers to a variety of compounds with the capacity to indirectly influence the function of the TOPORSL protein. This class includes several molecules that primarily target the topoisomerase enzymes, particularly TOP1, which shares a functional relationship with TOPORSL. Chemicals like camptothecin and its derivatives topotecan and irinotecan, which stabilize the TOP1-DNA cleavage complex, can impede the enzymatic activity necessary for DNA replication and transcription processes. The impact on TOP1 by these inhibitors has a downstream effect on TOPORSL, which is implicated in similar cellular functions.

Furthermore, the inclusion of TOP2 inhibitors in this class, such as etoposide, amsacrine, and mitoxantrone, represents a broader approach to modifying the cellular environment and DNA topology, potentially affecting TOPORSL function. These inhibitors can induce a cellular stress response and compromise the integrity of the DNA replication and repair mechanisms, which could, in turn, influence the role of TOPORSL. The molecules described here exhibit a wide range of structures and origins, including natural alkaloids, synthetic derivatives, and semisynthetic compounds. Each possesses the ability to alter the DNA metabolic processes in which TOPORSL might be implicated, thus indirectly modulating its activity.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Camptothecin

7689-03-4sc-200871
sc-200871A
sc-200871B
50 mg
250 mg
100 mg
$57.00
$182.00
$92.00
21
(2)

A quinoline alkaloid that inhibits TOP1 by stabilizing the TOP1-DNA cleavage complex, potentially affecting TOPORSL activity.

Topotecan Hydrochloride

119413-54-6sc-204919
sc-204919A
1 mg
5 mg
$44.00
$100.00
2
(1)

A topoisomerase inhibitor that binds to the TOP1-DNA complex, could indirectly affect TOPORSL through inhibition of TOP1.

(+)-Irinotecan

97682-44-5sc-269253
10 mg
$61.00
1
(1)

A semisynthetic derivative of camptothecin, targeting TOP1 and possibly influencing TOPORSL by altering DNA uncoiling processes.

β-Lapachone

4707-32-8sc-200875
sc-200875A
5 mg
25 mg
$110.00
$450.00
8
(1)

A natural naphthoquinone compound that targets TOP1, and can indirectly affect TOPORSL function.

Etoposide (VP-16)

33419-42-0sc-3512B
sc-3512
sc-3512A
10 mg
100 mg
500 mg
$32.00
$170.00
$385.00
63
(1)

A semisynthetic podophyllotoxin derivative that inhibits topoisomerase II, but might affect TOPORSL indirectly through cellular stress responses.

Amsacrine hydrochloride

54301-15-4sc-214540
10 mg
$232.00
(0)

An acridine derivative that inhibits topoisomerase II, but could influence TOPORSL through interference with DNA repair mechanisms.

Mitoxantrone

65271-80-9sc-207888
100 mg
$279.00
8
(1)

A synthetic anthraquinone that interferes with TOP2, might affect TOPORSL through perturbation of chromatin dynamics.

Teniposide

29767-20-2sc-204910
sc-204910A
25 mg
100 mg
$72.00
$230.00
6
(1)

A TOP2 inhibitor, could indirectly alter TOPORSL activity by modifying DNA topology and related cellular responses.

Ellipticine

519-23-3sc-200878
sc-200878A
10 mg
50 mg
$142.00
$558.00
4
(1)

An alkaloid that intercalates with DNA and inhibits TOP2, might indirectly affect TOPORSL.

Pixantrone

144510-96-3sc-481154
5 mg
$615.00
(0)

An aza-anthracenedione that acts on TOP2, can impact TOPORSL by affecting DNA synthesis and repair.