4930542N07Rik Activators
Chemical activators of spermatogenesis associated multipass transmembrane protein 4 employ a variety of intracellular signaling pathways to modulate the protein's activity. Calcium ionophore A23187 and ionomycin both function by increasing the intracellular concentration of calcium ions, which in turn activates calcium-dependent protein kinases. These kinases are responsible for phosphorylating numerous target proteins, including spermatogenesis associated multipass transmembrane protein 4, leading to its activation. Similarly, thapsigargin acts by disrupting calcium homeostasis, inhibiting the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) and resulting in an indirect activation of calcium-dependent processes that enhance the phosphorylation state of spermatogenesis associated multipass transmembrane protein 4.
Compounds such as forskolin, 8-Bromo-cyclic AMP, and dibutyryl cyclic AMP exert their effects by elevating the levels of cAMP within cells. The increase in cAMP activates protein kinase A (PKA), which then targets specific proteins for phosphorylation. Through this mechanism, spermatogenesis associated multipass transmembrane protein 4 is phosphorylated and activated. Phorbol 12-myristate 13-acetate (PMA), on the other hand, activates protein kinase C (PKC), which also leads to phosphorylation and subsequent activation of spermatogenesis associated multipass transmembrane protein 4. Alternatively, okadaic acid operates by inhibiting protein phosphatases, which normally act to dephosphorylate and deactivate proteins. This inhibition results in a sustained phosphorylated state of proteins within the signaling pathways, again culminating in the activation of spermatogenesis associated multipass transmembrane protein 4. Other compounds such as anisomycin and sphingosine 1-phosphate activate stress-activated protein kinases and sphingosine 1-phosphate receptors, respectively, which then initiate a cascade of events leading to the activation of spermatogenesis associated multipass transmembrane protein 4. Lastly, chelerythrine, by inhibiting certain isoforms of PKC, may indirectly cause the activation of alternative pathways that culminate in the activation of spermatogenesis associated multipass transmembrane protein 4.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
Calcium ionophore A23187 facilitates the influx of calcium ions, which can activate calmodulin-dependent kinase and other calcium-sensitive signaling pathways, leading to the activation of spermatogenesis associated multipass transmembrane protein 4 through phosphorylation events. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which phosphorylates and activates signaling proteins within pathways where spermatogenesis associated multipass transmembrane protein 4 is involved, resulting in its activation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin increases intracellular calcium concentration, thereby activating calcium-dependent protein kinases that can phosphorylate and activate spermatogenesis associated multipass transmembrane protein 4. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromo-cyclic AMP is a cAMP analog that activates cAMP-dependent pathways including protein kinase A (PKA), which can phosphorylate and activate spermatogenesis associated multipass transmembrane protein 4. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid inhibits protein phosphatases, leading to an increase in the phosphorylated state of proteins within signaling pathways associated with spermatogenesis associated multipass transmembrane protein 4, thereby promoting its activation. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl cyclic AMP, a cell-permeable cAMP analog, activates protein kinase A (PKA), and PKA then activates signaling pathways that include spermatogenesis associated multipass transmembrane protein 4, leading to its functional activation. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin disrupts calcium homeostasis by inhibiting the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA), leading to activation of calcium-dependent kinases that may result in the activation of spermatogenesis associated multipass transmembrane protein 4. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG has been shown to influence a variety of signaling pathways, including those involving calcium mobilization, which can lead to activation of kinases that activate spermatogenesis associated multipass transmembrane protein 4. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is known to activate stress-activated protein kinases, which can phosphorylate and activate spermatogenesis associated multipass transmembrane protein 4 within related signaling pathways. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine 1-phosphate activates sphingosine 1-phosphate receptors, which can initiate signaling cascades that result in the activation of spermatogenesis associated multipass transmembrane protein 4. | ||||||