4930527E24Rik Activators
Chemical activators of Slx-like 1 encompass a variety of compounds that modulate cellular signaling pathways to ultimately increase the phosphorylation state of the protein, thereby activating it. Forskolin and Dibutyryl-cAMP function by elevating intracellular levels of cAMP, a secondary messenger that activates protein kinase A (PKA). PKA, in turn, phosphorylates target proteins including Slx-like 1. Similarly, IBMX and Zaprinast prevent the degradation of cAMP and cGMP respectively by inhibiting phosphodiesterases, sustaining the activity of PKA or PKG, and promoting the phosphorylation and consequent activation of Slx-like 1. PMA, a known activator of protein kinase C (PKC), and Ionomycin, which increases intracellular calcium levels, can activate their respective kinases. PKC and calcium-dependent kinases may then phosphorylate Slx-like 1. Furthermore, the stress-activated protein kinases, which can be activated by Anisomycin, may also target Slx-like 1 for phosphorylation under stress conditions.
Inhibition of protein phosphatases is another route by which Slx-like 1 activation occurs. Compounds like Calyculin A, Okadaic Acid, and Cantharidin inhibit protein phosphatases 1 and 2A, leading to an increase in the phosphorylation levels of proteins. This inhibition prevents dephosphorylation of Slx-like 1, maintaining it in an activated state. Similarly, Staurosporine, although primarily a kinase inhibitor, can at low concentrations result in kinase activation, which may include those kinases that phosphorylate Slx-like 1. Lastly, Epigallocatechin gallate, which is known to inhibit various kinases, could affect the balance of kinase and phosphatase activities in the cell, leading to a state that favors Slx-like 1 activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterases, which prevents the breakdown of cAMP and cGMP. This leads to increased PKA activity, potentially resulting in the phosphorylation and subsequent activation of Slx-like 1. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA, or phorbol 12-myristate 13-acetate, activates protein kinase C (PKC), which can phosphorylate a variety of proteins. Activation of PKC can lead to downstream effects that may include the activation of Slx-like 1 through phosphorylation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Elevated calcium can activate calcium-dependent protein kinases, which might phosphorylate and activate Slx-like 1. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $160.00 $750.00 | 59 | |
Calyculin A is an inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A), leading to increased phosphorylation levels of proteins within the cell. This can result in the enhanced phosphorylation and activation of Slx-like 1. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid, similar to Calyculin A, is a potent inhibitor of PP1 and PP2A. Inhibition of these phosphatases can lead to phosphorylation and activation of Slx-like 1. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that can activate stress-activated protein kinases, such as JNK and p38 MAP kinase, which may contribute to the activation of Slx-like 1 through stress response signaling pathways. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate (EGCG) is known to inhibit several protein kinases and might activate Slx-like 1 through a compensatory mechanism that involves the rebalancing of kinase and phosphatase activities within the cell. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a cell-permeable cAMP analog that can directly activate PKA. Activation of PKA can lead to the phosphorylation and activation of Slx-like 1. | ||||||
Cantharidin | 56-25-7 | sc-201321 sc-201321A | 25 mg 100 mg | $81.00 $260.00 | 6 | |
Cantharidin is an inhibitor of protein phosphatases, particularly PP2A. By inhibiting dephosphorylation, this compound could lead to the sustained activation of Slx-like 1 through phosphorylation. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a non-specific kinase inhibitor, but at low concentrations, it can paradoxically activate certain kinases. This might result in the activation of Slx-like 1 through unexpected kinase pathway activation. | ||||||