1700022I11Rik Inhibitors
Chemical inhibitors of 1700022I11Rik can act through various mechanisms to inhibit the functional activity of the protein. Staurosporine and Bisindolylmaleimide I are two such inhibitors; Staurosporine is a broad-spectrum protein kinase inhibitor, which can prevent the phosphorylation activity necessary for the activation of many proteins, including 1700022I11Rik if it is regulated by kinases. Bisindolylmaleimide I specifically targets protein kinase C (PKC), and if 1700022I11Rik's function is regulated through PKC-mediated pathways, this inhibitor can effectively reduce its activity by competing with ATP at the catalytic site of PKC. Similarly, Genistein operates by inhibiting tyrosine kinases, which could affect 1700022I11Rik by preventing necessary phosphorylation on tyrosine residues. The inhibitor PD 98059 selectively targets MEK, a kinase within the ERK pathway, and would inhibit 1700022I11Rik if it is part of this signaling cascade by preventing the phosphorylation and activation of ERK itself.
Another set of inhibitors includes LY294002 and Wortmannin, both of which target phosphoinositide 3-kinases (PI3K). These inhibitors can suppress the activity of 1700022I11Rik by disrupting the PI3K pathway, which is often involved in cell survival and growth signals. Rapamycin, on the other hand, binds to mTOR complex and inhibits its activity, affecting 1700022I11Rik if its function is downstream of mTOR signaling. PP2 is a selective inhibitor for Src family tyrosine kinases. If Src kinases modulate the activity of 1700022I11Rik, then PP2 would result in the inhibition of its function as well. SB203580 and U0126 both serve as MAP kinase inhibitors, with SB203580 targeting p38 MAP kinase and U0126 inhibiting MEK. The inhibition of these kinases would prevent the activation of their respective signaling pathways, leading to the inhibition of 1700022I11Rik if it is a downstream effector. SP600125 inhibits JNK, which could result in the inhibition of 1700022I11Rik if it is involved in pathways related to apoptosis and inflammation that are regulated by JNK. Lastly, ZM-447439 is an Aurora kinase inhibitor, and if 1700022I11Rik plays a role in cell cycle regulation or mitotic processes where Aurora kinases are essential, then its inhibition by ZM-447439 would impair the proper function of 1700022I11Rik.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. 1700022I11Rik, if it operates through or within a kinase-dependent signaling pathway, would be functionally inhibited as Staurosporine inhibits the kinase's catalytic activity that would be responsible for the protein's phosphorylation and subsequent activation. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
Bisindolylmaleimide I is a specific inhibitor of protein kinase C (PKC). It inhibits PKC by competing with ATP for binding to the catalytic site of the enzyme. Inhibition of PKC can lead to the functional inhibition of 1700022I11Rik if the protein's activity is regulated through PKC-mediated signaling pathways. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor. It blocks the phosphorylation of proteins on tyrosine residues. If 1700022I11Rik requires tyrosine phosphorylation for its activity, the inhibition of these kinases by Genistein would result in a decrease in 1700022I11Rik activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD 98059 is a selective inhibitor of mitogen-activated protein kinase kinase (MEK). By inhibiting MEK, it prevents the activation of the extracellular signal-regulated kinase (ERK) pathway. 1700022I11Rik, when part of the ERK pathway, would be inhibited due to the blockade of this signaling route. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a specific inhibitor of phosphoinositide 3-kinases (PI3K). If 1700022I11Rik is downstream of PI3K signaling or requires PI3K activity, inhibition by LY294002 would lead to the functional inhibition of 1700022I11Rik. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin binds to mTOR complex (mTORC1) and inhibits its activity. If 1700022I11Rik functions downstream of mTOR signaling, inhibition by Rapamycin would suppress the functional activity of 1700022I11Rik due to the disruption of this growth-regulating pathway. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2 is a selective inhibitor of Src family tyrosine kinases. Src kinases are involved in various signaling pathways, and if 1700022I11Rik is activated by Src kinase signaling, the use of PP2 would inhibit its function. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a selective inhibitor of p38 MAP kinase. p38 MAP kinase is involved in stress responses and if 1700022I11Rik activity is modulated as part of the cellular stress response, inhibition by SB203580 would result in functional inhibition of 1700022I11Rik. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent inhibitor of phosphoinositide 3-kinases (PI3K). It inhibits PI3K by covalently binding to the catalytic site. If 1700022I11Rik is associated with the PI3K pathway, inhibition by Wortmannin would functionally inhibit 1700022I11Rik. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is a MEK inhibitor that prevents the activation of the ERK pathway. As a result, if 1700022I11Rik relies on the ERK pathway for its function, U0126 would inhibit this pathway and thereby inhibit the function of 1700022I11Rik. | ||||||