1700001K19Rik Inhibitors
Chemical inhibitors of 1700001K19Rik can act through various molecular pathways to inhibit its activity. PD98059 and U0126 are both inhibitors of the MAPK/ERK pathway, which is crucial for transmitting signals from cell surface receptors to DNA in the nucleus. By targeting MEK1/2, these compounds prevent the activation of ERK, a kinase that may phosphorylate 1700001K19Rik, thereby inhibiting its activity. SB203580 offers a similar level of specificity but within the p38 MAP kinase pathway. By inhibiting p38 MAP kinase, SB203580 can disrupt the response to stress signals and cytokines that might regulate 1700001K19Rik. SP600125 acts upon the JNK pathway, another MAP kinase pathway important for apoptosis and cell proliferation processes. Inhibition of JNK by SP600125 can thus inhibit 1700001K19Rik if it is a downstream target.
Inhibitors that target PI3K/AKT/mTOR signaling pathways, such as LY294002, Rapamycin, and Triciribine, can also regulate the activity of 1700001K19Rik. LY294002 inhibits PI3K, which leads to the inhibition of the AKT pathway, affecting the regulation of cellular processes that 1700001K19Rik may be a part of. Rapamycin specifically inhibits mTOR, a central protein in cell growth and proliferation signaling pathways. By inhibiting mTOR, Rapamycin can prevent the activation of downstream proteins, including 1700001K19Rik. Triciribine directly inhibits AKT phosphorylation and activation, which would lead to the inhibition of 1700001K19Rik if it is involved in AKT signaling. Erlotinib and Gefitinib both inhibit the EGFR tyrosine kinase, which is at the forefront of a cell signaling cascade. The inhibition of EGFR by these compounds can prevent the activation of downstream signaling cascades that may involve 1700001K19Rik. PP2 targets Src family tyrosine kinases, and by inhibiting these kinases, it can disrupt signaling pathways that regulate cell proliferation and survival, which can inhibit the activity of 1700001K19Rik. Lastly, Staurosporine, as a non-selective kinase inhibitor, can broadly inhibit kinase activity, affecting various signaling pathways that include kinases which may directly or indirectly regulate 1700001K19Rik activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a specific inhibitor of mitogen-activated protein kinase kinase (MEK), which blocks the MAPK/ERK pathway. By inhibiting MEK, this compound would prevent the phosphorylation and activation of downstream targets, including 1700001K19Rik, assuming its activity is regulated through this pathway. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is an inhibitor of phosphoinositide 3-kinases (PI3K). By interfering with PI3K activity, LY294002 would inhibit the PI3K/AKT pathway, which is involved in numerous cellular processes including metabolism, growth, proliferation, and survival that could be crucial for the functional regulation of 1700001K19Rik. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 selectively inhibits MEK1 and MEK2, which are central components of the MAPK/ERK pathway. The inhibition of MEK activity would prevent the activation of ERK and subsequent phosphorylation of proteins that are downstream in this signaling cascade, potentially including 1700001K19Rik. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is a well-known inhibitor of the mammalian target of rapamycin (mTOR) pathway. By inhibiting mTOR, Rapamycin would disrupt downstream signaling that regulates cell growth, proliferation, and survival, possibly leading to the inhibition of 1700001K19Rik's function if it is part of the mTOR signaling network. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAP kinase. Inhibition of p38 MAP kinase by SB203580 would disrupt its role in response to stress signals and cytokines, potentially leading to inhibition of 1700001K19Rik if it is a downstream effector in the p38 MAPK signaling pathway. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK), which is implicated in controlling apoptosis and cell proliferation. By blocking JNK activity, SP600125 could inhibit the function of 1700001K19Rik if JNK signaling is necessary for its activity. | ||||||
Erlotinib, Free Base | 183321-74-6 | sc-396113 sc-396113A sc-396113B sc-396113C sc-396113D | 500 mg 1 g 5 g 10 g 100 g | $87.00 $135.00 $293.00 $505.00 $3827.00 | 42 | |
Erlotinib selectively inhibits epidermal growth factor receptor (EGFR) tyrosine kinase, which could lead to the inhibition of downstream signaling pathways including those that may involve 1700001K19Rik, thereby inhibiting the protein's function. | ||||||
Gefitinib | 184475-35-2 | sc-202166 sc-202166A sc-202166B sc-202166C | 100 mg 250 mg 1 g 5 g | $63.00 $114.00 $218.00 $349.00 | 74 | |
Gefitinib is an EGFR inhibitor that blocks the kinase activity of the receptor. By inhibiting EGFR, Gefitinib would prevent the activation of downstream signaling cascades that could include 1700001K19Rik, leading to its functional inhibition. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2 is an inhibitor of Src family tyrosine kinases. By inhibiting Src kinase activity, PP2 could disrupt signaling pathways that regulate cell proliferation and survival, potentially leading to the inhibition of 1700001K19Rik if it is involved in these pathways. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $104.00 $141.00 | 14 | |
Triciribine specifically inhibits the AKT pathway by preventing AKT phosphorylation and activation. If 1700001K19Rik functions downstream of AKT, its activity would be inhibited as a result of this compound's action. | ||||||