17-β Estradiol 6 Inhibitors
17-β Estradiol 6 inhibitors consist of specific chemical entities that can diminish the functional activity of 17-β Estradiol 6, a protein that exerts its biological effects through the estrogen receptor. These inhibitors primarily include selective estrogen receptor modulators (SERMs) and aromatase inhibitors. SERMs such as Tamoxifen, Raloxifene, Toremifene, and Clomiphene function by binding to the estrogen receptor, inhibiting 17-β Estradiol 6 from binding and exerting its effects. This action disrupts the signaling pathways initiated by 17-β Estradiol 6, leading to its functional inhibition. Prinaberel also acts as an estrogen receptor antagonist, disrupting the signal transduction initiated by 17-β Estradiol 6 and leading to its functional inhibition.
Aromatase inhibitors such as Letrozole, Anastrozole, Exemestane, and Formestane function by inhibiting the synthesis of estrogen, leading to a reduction in estrogen levels, which indirectly leads to the decreased functional activity of 17-β Estradiol 6. These inhibitors effectively block the enzymatic conversion of androgens to estrogens, which disrupts the availability of 17-β Estradiol 6 for binding to its receptor, thereby inhibiting its functional activity. The inhibitor Mifepristone acts as a progesterone receptor antagonist but also exhibits antagonistic effects on glucocorticoid receptors. The action of Mifepristone can indirectly lead to decreased functional activity of 17-β Estradiol 6 due to cross-talk between these hormonal pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
ICI 182,780 | 129453-61-8 | sc-203435 sc-203435A | 1 mg 10 mg | $83.00 $187.00 | 34 | |
Fulvestrant is an estrogen receptor antagonist that binds to the receptor and promotes its degradation. As 17-β Estradiol 6 acts through estrogen receptors, Fulvestrant's antagonistic action leads to the decreased functional activity of 17-β Estradiol 6. | ||||||
Tamoxifen | 10540-29-1 | sc-208414 | 2.5 g | $272.00 | 18 | |
Tamoxifen is a selective estrogen receptor modulator (SERM) that interferes with the binding of estrogen to its receptor. This inhibition disrupts the signal transduction initiated by 17-β Estradiol 6, thus decreasing its functional activity. | ||||||
Raloxifene | 84449-90-1 | sc-476458 | 1 g | $802.00 | 3 | |
Raloxifene is a SERM that binds to estrogen receptors, preventing 17-β Estradiol 6 from exerting its effects, thus inhibiting its functional activity. | ||||||
Toremifene citrate | 89778-27-8 | sc-253712 | 100 mg | $100.00 | 3 | |
Toremifene is a SERM that binds to estrogen receptors, disrupting the signal transduction triggered by 17-β Estradiol 6, resulting in its functional inhibition. | ||||||
Letrozole | 112809-51-5 | sc-204791 sc-204791A | 25 mg 50 mg | $87.00 $147.00 | 5 | |
Letrozole is an aromatase inhibitor that prevents the synthesis of estrogen. This reduction of estrogen levels indirectly leads to the decreased functional activity of 17-β Estradiol 6. | ||||||
Anastrozole | 120511-73-1 | sc-217647 | 10 mg | $92.00 | 1 | |
Anastrozole is an aromatase inhibitor that reduces the level of estrogen. This action indirectly leads to the decreased functional activity of 17-β Estradiol 6. | ||||||
Exemestane | 107868-30-4 | sc-203045 sc-203045A | 25 mg 100 mg | $134.00 $411.00 | ||
Exemestane is an aromatase inhibitor that reduces estrogen levels, thereby indirectly decreasing the functional activity of 17-β Estradiol 6. | ||||||
ERB 041 | 524684-52-4 | sc-362734 sc-362734A | 10 mg 50 mg | $223.00 $895.00 | ||
Prinaberel is an estrogen receptor antagonist that disrupts the signal transduction initiated by 17-β Estradiol 6, leading to its functional inhibition. | ||||||
Mifepristone | 84371-65-3 | sc-203134 | 100 mg | $61.00 | 17 | |
Mifepristone is a progesterone receptor antagonist that also exhibits antagonistic effects on glucocorticoid receptors. Its action can indirectly lead to decreased functional activity of 17-β Estradiol 6 due to cross-talk between these hormonal pathways. | ||||||
Danazol | 17230-88-5 | sc-203021 sc-203021A | 100 mg 250 mg | $92.00 $238.00 | 3 | |
Danazol is a synthetic steroid that possesses antigonadotropic properties, leading to decreased estrogen levels and thus indirectly inhibiting the functional activity of 17-β Estradiol 6. | ||||||