Molecular structure of ERB 041, CAS Number: 524684-52-4
ERB 041 (CAS 524684-52-4)
Alternate Names:
Prinaberel; 7-Ethenyl-2-(3-fluoro-4-hydroxyphenyl)-5-benzoxazolol
Application:
ERB 041 is a potent agonist of ERβ
CAS Number:
524684-52-4
Molecular Weight:
271.24
Molecular Formula:
C15H10FNO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
ERB 041 is a potent ERβ (Estrogen Receptor beta) agonist demonstrating >200-fold selectivity for ERβ over ERα (IC50 values of 5 and 1216 nM for human ERβ and ERα respectively).
ERB 041 (CAS 524684-52-4) References
- Organ messenger ribonucleic acid and plasma proteome changes in the adjuvant-induced arthritis model: responses to disease induction and therapy with the estrogen receptor-beta selective agonist ERB-041. | Follettie, MT., et al. 2006. Endocrinology. 147: 714-23. PMID: 16269464
- ERB-041, a selective ER beta agonist, inhibits iNOS production in LPS-activated peritoneal macrophages of endometriosis via suppression of NF-kappaB activation. | Xiu-li, W., et al. 2009. Mol Immunol. 46: 2413-8. PMID: 19447495
- Efficacy and safety of a selective estrogen receptor β agonist, ERB-041, in patients with rheumatoid arthritis: a 12-week, randomized, placebo-controlled, phase II study. | Roman-Blas, JA., et al. 2010. Arthritis Care Res (Hoboken). 62: 1588-93. PMID: 20556817
- Erb-041, an estrogen receptor-β agonist, inhibits skin photocarcinogenesis in SKH-1 hairless mice by downregulating the WNT signaling pathway. | Chaudhary, SC., et al. 2014. Cancer Prev Res (Phila). 7: 186-98. PMID: 24217507
- Estrogen receptor modulators genistein, daidzein and ERB-041 inhibit cell migration, invasion, proliferation and sphere formation via modulation of FAK and PI3K/AKT signaling in ovarian cancer. | Chan, KKL., et al. 2018. Cancer Cell Int. 18: 65. PMID: 29743815
- Estrogen Receptors Promote Migration, Invasion and Colony Formation of the Androgen-Independent Prostate Cancer Cells PC-3 Through β-Catenin Pathway. | Lombardi, APG., et al. 2020. Front Endocrinol (Lausanne). 11: 184. PMID: 32328032
- Tumour-suppressive effect of oestrogen receptor β in colorectal cancer patients, colon cancer cells, and a zebrafish model. | Topi, G., et al. 2020. J Pathol. 251: 297-309. PMID: 32333795
- Carcinogenesis of Triple-Negative Breast Cancer and Sex Steroid Hormones. | Honma, N., et al. 2021. Cancers (Basel). 13: PMID: 34070471
- Keratinocyte Carcinoma and Photoprevention: The Protective Actions of Repurposed Pharmaceuticals, Phytochemicals and Vitamins. | Pihl, C., et al. 2021. Cancers (Basel). 13: PMID: 34359586
- Estrogen receptor β alleviates inflammatory lesions in a rat model of inflammatory bowel disease via down-regulating P2X7R expression in macrophages. | Jiang, Q., et al. 2021. Int J Biochem Cell Biol. 139: 106068. PMID: 34464722
- Estrogen Receptors in Colorectal Cancer: Facts, Novelties and Perspectives. | Ditonno, I., et al. 2021. Curr Oncol. 28: 4256-4263. PMID: 34898546
- Therapeutic Strategies and Potential Actions of Female Sex Steroid Hormones and Their Receptors in Colon Cancer Based on Preclinical Studies. | Mahbub, AA. 2022. Life (Basel). 12: PMID: 35455096
- A Novel Estrogen Receptor β Agonist Diminishes Ovarian Cancer Stem Cells via Suppressing the Epithelial-to-Mesenchymal Transition. | Banerjee, A., et al. 2022. Cancers (Basel). 14: PMID: 35565440
- Development of a Novel 18F-Labeled Probe for PET Imaging of Estrogen Receptor β. | Zhou, Y., et al. 2023. J Med Chem. 66: 1210-1220. PMID: 36602888
Inhibitor of:
17-β Estradiol 6, ER beta, FSH, Gm694, and Transcription Factor.Activator of:
ER beta, and ERRα.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ERB 041, 10 mg | sc-362734 | 10 mg | $223.00 | |||
ERB 041, 50 mg | sc-362734A | 50 mg | $895.00 |