17-β Estradiol 6 Antibody (4A7): sc-69958

17-β Estradiol 6 Antibody (4A7) is a mouse monoclonal IgG1 antibody that detects 17-beta Estradiol 6 of human origin by enzyme-linked immunosorbent assay (ELISA). Anti-17-beta Estradiol 6 antibody (4A7) is available as a non-conjugated monoclonal isotype antibody, providing researchers with a reliable tool for studying this critical hormone. 17-β Estradiol is a potent mammalian estrogenic hormone primarily produced in the ovaries by granulosa cells, as well as in the placenta, testis, and potentially the adrenal cortex. The synthesis of 17-β Estradiol involves enzymatic conversion from precursors such as acetate, cholesterol, progesterone, and testosterone. 17-β Estradiol′s role extends beyond the regulation of reproductive systems and secondary sex characteristics; this hormone is also vital for bone growth, brain development, and the modulation of intracellular calcium levels and second messenger molecules. Research has shown that 17-β Estradiol exerts protective effects on various cell types following trauma-hemorrhage, enhancing circulation through aortic relaxation and exhibiting anti-apoptotic properties in endothelial cells. Additionally, 17-β Estradiol plays a significant role in mitigating hydrogen peroxide-induced apoptosis via estrogen receptor-dependent activation of caspases-9 and -3 in rat endothelial cells, highlighting this hormone′s importance in cellular survival and function.

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17-β Estradiol 6 Antibody (4A7) References:

1. The atheroprotective effect of 17 beta-estradiol is not altered in P-selectin- or ICAM-1-deficient hypercholesterolemic mice.  |  Gourdy, P., et al. 2003. Atherosclerosis. 166: 41-8. PMID: 12482549
2. Dose-dependent inhibition of mitochondrial ATP synthase by 17 beta-estradiol.  |  Massart, F., et al. 2002. Gynecol Endocrinol. 16: 373-7. PMID: 12587531
3. Biphasic effects of 17-beta-estradiol on expression of occludin and transendothelial resistance and paracellular permeability in human vascular endothelial cells.  |  Ye, L., et al. 2003. J Cell Physiol. 196: 362-9. PMID: 12811830
4. 17 beta-estradiol/levonorgestrel transdermal system.  |  Dando, TM. and Perry, CM. 2004. Treat Endocrinol. 3: 319-24. PMID: 15330679
5. 17 Beta-estradiol-induced antidepressant-like effect in the forced swim test is absent in estrogen receptor-beta knockout (BERKO) mice.  |  Rocha, BA., et al. 2005. Psychopharmacology (Berl). 179: 637-43. PMID: 15645223
6. Short-term administration of 17-beta estradiol to outbred male CD-1 mice induces changes in the immune system, but not in reproductive organs.  |  Karpuzoglu-Sahin, E., et al. 2005. Immunol Invest. 34: 1-26. PMID: 15773569
7. Intranasal continuous combined 17 beta-estradiol/norethisterone therapy improves the lipid profile in healthy postmenopausal women.  |  Hemelaar, M., et al. 2006. Fertil Steril. 85: 979-88. PMID: 16580384
8. 17 beta-estradiol administration following trauma-hemorrhage prevents the increase in Kupffer cell cytokine production and MAPK activation predominately via estrogen receptor-alpha.  |  Suzuki, T., et al. 2006. Surgery. 140: 141-8. PMID: 16904963
9. 17-beta-Estradiol upregulates COX-2 in the rat oviduct.  |  Pérez Martínez, S., et al. 2006. Prostaglandins Other Lipid Mediat. 80: 155-64. PMID: 16939880

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-17-β Estradiol 6 Antibody (4A7) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-17-β Estradiol 6 Antibody (4A7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

17-β Estradiol 6 Antibody (4A7) Specifications

Alternate Product Name: 17-β Estradiol 6

Product Clone Name: 4A7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: 17-β Estradiol 6

Epitope Species: human

Product Reactivity/Detection: 17-β Estradiol 6

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: ELISA

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for 17-β Estradiol 6 Antibody (4A7): N/A