1500016O10Rik Inhibitors
Chemical inhibitors of 1500016O10Rik target various signaling pathways to reduce the activity of this protein. Wortmannin and LY294002 are both inhibitors of phosphoinositide 3-kinases (PI3K), which play a pivotal role in the PI3K/AKT/mTOR pathway, a crucial signaling cascade that regulates numerous cellular processes. By inhibiting PI3K, these chemicals can lead to decreased activation of AKT, a serine/threonine kinase that directly influences the function of downstream proteins, including 1500016O10Rik. Triciribine and MK-2206 also target the AKT pathway but act more downstream by directly inhibiting AKT itself. This inhibition reduces the phosphorylation and activation of several proteins, including 1500016O10Rik, which is often regulated by AKT-mediated signaling.
Additionally, Rapamycin, through its interaction with FKBP12, specifically inhibits mTORC1, which is another crucial component of the cell growth and proliferation signaling network that can affect 1500016O10Rik activity. In parallel, compounds such as U0126, PD98059, and SL327 exert their effects by inhibiting MEK1/2, which is upstream of ERK1/2 in the MAPK pathway. These inhibitors prevent the activation of ERK, thereby decreasing the ERK-mediated signaling that can regulate the activity of proteins like 1500016O10Rik. Furthermore, SP600125 and SB203580 inhibit the JNK and p38 MAPK pathways, respectively, both of which can contribute to the regulation of 1500016O10Rik activity within the cell. Lastly, PP2 and Dasatinib are known to inhibit Src family kinases, which are involved in multiple signaling pathways that can converge on the regulation of 1500016O10Rik function. By targeting these kinases, PP2 and Dasatinib can effectively reduce the signaling that typically activates 1500016O10Rik.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin inhibits PI3K, which is involved in the AKT signaling pathway. Inhibition of PI3K can decrease the activation of AKT, thereby reducing the phosphorylation and activity of downstream targets including 1500016O10Rik. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a specific inhibitor of PI3K, leading to the inhibition of the PI3K/AKT/mTOR pathway. By inhibiting PI3K, this chemical can decrease AKT activity, which in turn may lead to reduced influence on 1500016O10Rik activity due to decreased signaling. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin binds to FKBP12 and inhibits mTORC1, which is crucial in cell growth and proliferation signals that can affect the activity of 1500016O10Rik through downstream signaling pathways. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $102.00 $138.00 | 14 | |
Triciribine acts to inhibit AKT phosphorylation and activation. By directly inhibiting AKT, triciribine can reduce the downstream phosphorylation events that would otherwise influence 1500016O10Rik activity. | ||||||
MK-2206 dihydrochloride | 1032350-13-2 | sc-364537 sc-364537A | 5 mg 10 mg | $178.00 $325.00 | 67 | |
MK-2206 is an allosteric inhibitor of AKT, which can decrease the phosphorylation and subsequent activity of proteins regulated by AKT, such as 1500016O10Rik. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 inhibits MEK1/2, which are upstream of ERK1/2 in the MAPK pathway. Inhibition here can decrease ERK-mediated phosphorylation events that may regulate 1500016O10Rik function. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
SP600125 is an inhibitor of JNK, which by inhibiting can reduce the JNK signaling pathway's influence on 1500016O10Rik activity through downstream effects. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 inhibits p38 MAPK, which can lead to decreased p38 MAPK-mediated signaling pathways that are known to regulate the activity of proteins such as 1500016O10Rik. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 inhibits Src family kinases, which participate in multiple signaling pathways that can regulate the function of proteins like 1500016O10Rik. By inhibiting Src kinases, PP2 can reduce the signaling pathways that activate 1500016O10Rik. | ||||||
SL-327 | 305350-87-2 | sc-200685 sc-200685A | 1 mg 10 mg | $107.00 $332.00 | 7 | |
SL327 is known to inhibit MEK, leading to decreased activation of ERK MAPK. This can result in lower activity of downstream proteins influenced by ERK, including 1500016O10Rik. | ||||||