KLF16 Activators
KLF16 Activators are chemicals that can increase the functional activity of KLF16, a protein that plays a vital role as a transcriptional repressor in the NF-κB pathway. These activators work by interacting with the NF-κB pathway, which KLF16 is directly involved in. For instance, Triptolide is a potent inhibitor of NF-κB, enhancing the functional activity of KLF16 by increasing the demand for its role as a transcriptional repressor within this pathway. Similarly, JSH-23, an inhibitor of NF-κB that blocks its nuclear translocation, and Parthenolide, another NF-κB inhibitor, can enhance the functional activity of KLF16 by increasing the need for its repressive role in the NF-κB pathway. BAY 11-7082 and BAY 11-7085, both irreversible inhibitors of NF-κB activation, work in a similar manner. PDTC, another potent inhibitor of NF-κB, also enhances the functional activity of KLF16 by increasing its functional demand within the NF-κB pathway.
Another group of KLF16 activators are proteasome inhibitors. The proteasome is responsible for the degradation of KLF16, and inhibiting this degradation process can enhance the functional activity of KLF16. This group includes compounds such as MG-132, a potent and reversible proteasome inhibitor. Similarly, Lactacystin, a highly specific and potent proteasome inhibitor, can increase the levels and functional activity of KLF16 by inhibiting the proteasome. Epoxomicin, a potent and selective proteasome inhibitor, works in a similar manner. Clasto-Lactacystin β-lactone, AM114, and MLN2238, all proteasome inhibitors, can increase the levels and functional activity of KLF16 by inhibiting the proteasome. Therefore, these inhibitors can enhance the functional activity of KLF16 by preventing its degradation, leading to an increase in the protein's levels and activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide is a potent inhibitor of NF-κB, a pathway with which KLF16 interacts. By inhibiting NF-κB, Triptolide enhances the functional activity of KLF16 which acts as a transcriptional repressor in this pathway. | ||||||
NFκB Activation Inhibitor II, JSH-23 | 749886-87-1 | sc-222061 sc-222061C sc-222061A sc-222061B | 5 mg 10 mg 50 mg 100 mg | $214.00 $257.00 $1775.00 $2003.00 | 34 | |
JSH-23 is a NF-κB inhibitor that blocks its nuclear translocation. KLF16 acts as a transcriptional repressor in the NF-κB pathway, therefore, JSH-23 indirectly enhances the activity of KLF16 by increasing the demand for its role in this pathway. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Parthenolide is an NF-κB inhibitor. By inhibiting NF-κB, Parthenolide can increase the demand for KLF16, enhancing its functional activity as a transcriptional repressor in this pathway. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
BAY 11-7082 irreversibly inhibits NF-κB activation. This enhances the functional activity of KLF16, which acts as a transcriptional repressor in the NF-κB pathway. | ||||||
BAY 11-7085 | 196309-76-9 | sc-202490 sc-202490A | 10 mg 50 mg | $124.00 $526.00 | 55 | |
BAY 11-7085 irreversibly inhibits NF-κB activation. By doing so, it increases the demand for KLF16, enhancing its functional activity as a transcriptional repressor in the NF-κB pathway. | ||||||
Pyrrolidinedithiocarbamic acid ammonium salt | 5108-96-3 | sc-203224 sc-203224A | 5 g 25 g | $33.00 $64.00 | 11 | |
PDTC is a potent inhibitor of NF-κB. Its inhibition of NF-κB enhances the functional activity of KLF16, which acts as a transcriptional repressor in the NF-κB pathway. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG-132 is a potent, reversible, and cell-permeable proteasome inhibitor. KLF16 is known to be degraded by the proteasome, therefore, inhibition of the proteasome can lead to an increase in KLF16 levels and consequently its functional activity. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $137.00 $219.00 $449.00 $506.00 | 19 | |
Epoxomicin is a potent, irreversible and selective proteasome inhibitor. It can increase the levels and functional activity of KLF16 by inhibiting the proteasome, which is responsible for KLF16 degradation. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $188.00 $575.00 | 60 | |
Lactacystin is a highly specific and potent inhibitor of the proteasome. By inhibiting the proteasome, which is responsible for KLF16 degradation, Lactacystin can enhance the levels and functional activity of KLF16. | ||||||
Ixazomib | 1072833-77-2 | sc-489103 sc-489103A | 10 mg 50 mg | $311.00 $719.00 | ||
MLN2238 is a potent inhibitor of the proteasome. By inhibiting the proteasome, MLN2238 can enhance the levels and functional activity of KLF16. | ||||||