KLF16 Antibody (F-4): sc-377519

KLF16 Antibody (F-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects KLF16 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-KLF16 antibody (F-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Krüppel-like factor 16 (KLF16), also known as BTEB4, dopamine receptor-regulating factor (DRRF), or NSLP2, is a 252 amino acid protein characterized by three C2H2-type zinc fingers, which are crucial for its role as a transcription factor. KLF16 is primarily localized in the nucleus and is highly expressed in the brain, where KLF16 plays a significant role in modulating dopaminergic transmission by binding specifically to GT and GC boxes. KLF16′s ability to displace transcription factors such as Sp1 and Sp3 highlights KLF16′s importance in regulating gene expression related to cell growth and differentiation, making KLF16 a vital player in both normal physiological processes and potential pathological conditions. Anti-KLF16 antibody (F-4) versatility in various applications allows researchers to explore the multifaceted roles of KLF16 in cellular mechanisms and its implications in neurobiology.

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KLF16 Antibody (F-4) References:

1. Dopamine receptor regulating factor, DRRF: a zinc finger transcription factor.  |  Hwang, CK., et al. 2001. Proc Natl Acad Sci U S A. 98: 7558-63. PMID: 11390978
2. A conserved alpha-helical motif mediates the interaction of Sp1-like transcriptional repressors with the corepressor mSin3A.  |  Zhang, JS., et al. 2001. Mol Cell Biol. 21: 5041-9. PMID: 11438660
3. Developmental expression of the zinc finger transcription factor DRRF (dopamine receptor regulating factor).  |  D'Souza, UM., et al. 2002. Mech Dev. 110: 197-201. PMID: 11744383
4. Functional analysis of basic transcription element (BTE)-binding protein (BTEB) 3 and BTEB4, a novel Sp1-like protein, reveals a subfamily of transcriptional repressors for the BTE site of the cytochrome P4501A1 gene promoter.  |  Kaczynski, JA., et al. 2002. Biochem J. 366: 873-82. PMID: 12036432
5. Genomic organization and promoter characterization of the murine dopamine receptor regulating factor (DRRF) gene.  |  Lee, SH., et al. 2003. Gene. 304: 193-9. PMID: 12568728
6. Cell and tissue specific expression of human Krüppel-like transcription factors in human ocular surface.  |  Chiambaretta, F., et al. 2004. Mol Vis. 10: 901-9. PMID: 15570219
7. Identification of the imprinted KLF14 transcription factor undergoing human-specific accelerated evolution.  |  Parker-Katiraee, L., et al. 2007. PLoS Genet. 3: e65. PMID: 17480121
8. Analysis of KLF transcription factor family gene variants in type 2 diabetes.  |  Gutiérrez-Aguilar, R., et al. 2007. BMC Med Genet. 8: 53. PMID: 17688680
9. F-box/LRR-repeat protein 7 is genetically associated with Alzheimer's disease.  |  Tosto, G., et al. 2015. Ann Clin Transl Neurol. 2: 810-20. PMID: 26339675
10. F-Box Proteins and Cancer.  |  Yumimoto, K., et al. 2020. Cancers (Basel). 12: PMID: 32429232
11. F-box only protein 9 and its role in cancer.  |  Hussain, S., et al. 2022. Mol Biol Rep. 49: 1537-1544. PMID: 35025031
12. Inhibitors Targeting the F-BOX Proteins.  |  Naseem, Y., et al. 2023. Cell Biochem Biophys. 81: 577-597. PMID: 37624574

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-KLF16 Antibody (F-4) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-KLF16 Antibody (F-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

KLF16 Antibody (F-4) Specifications

Alternate Product Name: KLF16

Product Clone Name: F-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 207-252

Epitope Target: KLF16

Epitope Species: human

Product Reactivity/Detection: KLF16

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for KLF16 Antibody (F-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin