HORMAD1 Inhibitors
Chemical inhibitors of HORMAD1 can function through the disruption of microtubule dynamics, a cellular process essential for meiotic chromosome alignment and segregation, activities central to the role of HORMAD1. Paclitaxel (Taxol), for instance, stabilizes microtubules, preventing their disassembly which is necessary for the proper function of HORMAD1 during meiosis. Similarly, Griseofulvin and Podophyllotoxin bind to tubulin, the building block of microtubules, hindering their polymerization and subsequently the cell division process where HORMAD1 operates. Colchicine also binds to tubulin, but it inhibits its polymerization, leading to a failure in the formation of meiotic spindles, which are essential for the chromosomal functions involving HORMAD1. Vinblastine and Vincristine follow a similar mechanism, where their binding to tubulin leads to an interference in microtubule formation, thus indirectly inhibiting the activities of HORMAD1 associated with chromosome dynamics during meiosis.
In addition to the aforementioned compounds, chemicals like Nocodazole and Eribulin alter microtubule formation by either depolymerizing microtubules or inhibiting their growth phase, respectively. These actions result in abnormal mitotic spindles, indirectly inhibiting HORMAD1 by disrupting the cell division processes that are foundational to HORMAD1's function in meiosis. Monastrol, another kinesin Eg5 inhibitor, impedes spindle formation, leading to cell cycle arrest at a stage where HORMAD1 is active, thus indirectly inhibiting its function. Combretastatin A4, which binds to the colchicine site on tubulin, mirrors this effect by preventing microtubule assembly, and thereby the actions of HORMAD1 in meiosis. Lastly, Thiabendazole's interference with microtubule polymerization affects the assembly of meiotic spindles, which is a corequisite for the chromosomal processes in which HORMAD1 is a key participant, thereby functionally inhibiting the protein. Each of these chemicals acts on the microtubule dynamics to indirectly inhibit HORMAD1 by affecting the cellular structures and processes that are fundamental for its function in meiotic chromosome segregation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and as such can inhibit cell division. HORMAD1 is involved in meiotic cell cycles; by stabilizing microtubules, Paclitaxel can disrupt meiotic progression where HORMAD1 is essential, leading to functional inhibition of HORMAD1 activity due to disrupted chromosomal dynamics. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Monastrol is a kinesin Eg5 inhibitor that disrupts mitotic spindle formation. HORMAD1's role in chromosome synapsis and segregation during meiosis can be indirectly inhibited by Monastrol's effect on spindle assembly, leading to meiotic arrest and therefore functional inhibition of HORMAD1 due to failure in proper chromosome alignment and movement. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
Griseofulvin disrupts microtubule function by binding to tubulin, which can interfere with microtubule dynamics. As HORMAD1 has a role in meiotic chromosomes, the action of Griseofulvin can lead to disrupted cell division processes where HORMAD1 is active, which can indirectly result in the functional inhibition of HORMAD1. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole is a microtubule depolymerizing agent. It can lead to cell cycle arrest by disrupting microtubule polymerization. Given that HORMAD1 is involved in the meiotic cell cycle, the action of Nocodazole can indirectly inhibit HORMAD1 function by preventing the proper formation of the meiotic spindle, thus impacting chromosome segregation where HORMAD1 is involved. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine binds to tubulin, inhibiting microtubule polymerization. Interruption in microtubule formation can indirectly inhibit HORMAD1 by disrupting meiotic spindles and thus impairing the processes of chromosome pairing and segregation, which are crucial to HORMAD1's function. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $84.00 | 1 | |
Podophyllotoxin inhibits tubulin polymerization, leading to the disruption of mitotic spindle formation. By affecting spindle dynamics, Podophyllotoxin can indirectly inhibit HORMAD1 function in meiotic chromosome segregation and pairing, integral processes for HORMAD1's role in meiosis. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine interferes with microtubule formation by binding to tubulin. This can inhibit cell division, which indirectly interferes with HORMAD1's function in meiotic chromosome alignment and segregation. | ||||||
Combrestatin A4 | 117048-59-6 | sc-204697 sc-204697A | 1 mg 5 mg | $46.00 $81.00 | ||
Combretastatin A4 binds to tubulin at the colchicine site and inhibits microtubule assembly. This can lead to an indirect functional inhibition of HORMAD1 by affecting the microtubule dynamics required for chromosome segregation and pairing in meiosis. | ||||||
Eribulin | 253128-41-5 | sc-507547 | 5 mg | $865.00 | ||
Eribulin inhibits the growth phase of microtubules without affecting the shortening phase, leading to abnormal mitotic spindles. This action can indirectly inhibit HORMAD1 function by disrupting meiotic spindle formation, which is essential for HORMAD1's role in chromosome segregation. | ||||||
Thiabendazole | 148-79-8 | sc-204913 sc-204913A sc-204913B sc-204913C sc-204913D | 10 g 100 g 250 g 500 g 1 kg | $32.00 $84.00 $183.00 $312.00 $572.00 | 5 | |
Thiabendazole interferes with microtubule polymerization. Since HORMAD1 is involved in meiotic chromosome processes, this disruption can lead to a functional inhibition by impacting the proper assembly of meiotic spindles, thus affecting chromosome dynamics where HORMAD1 is crucial. | ||||||