HORMAD1 Antibody (GG-Y): sc-101235

HORMAD1 Antibody (GG-Y) is a mouse monoclonal IgG1 kappa light chain antibody that detects HORMAD1 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-HORMAD1 antibody (GG-Y) is available as a non-conjugated format. HORMAD1, also known as HORMA domain containing 1, NOHMA (Newborn Ovary HORMA protein), or CT46 (Cancer/Testis antigen 46), is a 394 amino acid testis-specific protein that plays a crucial role in meiosis and chromatin dynamics. HORMAD1 contains a single HORMA (Hop1p, Rev7p, and MAD2) domain, which is essential for chromatin binding and recruiting other proteins to chromatin states, particularly during critical cellular processes such as DNA double-strand breaks and nonattachment to the mitotic spindle. This recruitment maintains genomic stability and facilitates proper meiotic progression. HORMAD1 is overexpressed in various carcinomas, including breast, lung, endometrial, colon, bladder, and esophageal cancers, highlighting potential as a biomarker for cancer diagnosis and treatment. HORMAD1′s interaction with other proteins involved in chromatin remodeling further underscores importance in both normal cellular function and disease states.

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HORMAD1 Antibody (GG-Y) References:

1. Restricted germ cell expression of a gene encoding a novel mammalian HORMA domain-containing protein.  |  Pangas, SA., et al. 2004. Gene Expr Patterns. 5: 257-63. PMID: 15567723
2. Identification of CT46/HORMAD1, an immunogenic cancer/testis antigen encoding a putative meiosis-related protein.  |  Chen, YT., et al. 2005. Cancer Immun. 5: 9. PMID: 15999985
3. Systematic search for gastric cancer-specific genes based on SAGE data: melanoma inhibitory activity and matrix metalloproteinase-10 are novel prognostic factors in patients with gastric cancer.  |  Aung, PP., et al. 2006. Oncogene. 25: 2546-57. PMID: 16331256
4. Integrated profiling of basal and luminal breast cancers.  |  Adélaïde, J., et al. 2007. Cancer Res. 67: 11565-75. PMID: 18089785

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HORMAD1 Antibody (GG-Y) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-HORMAD1 Antibody (GG-Y) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HORMAD1 Antibody (GG-Y) Specifications

Alternate Product Name: HORMAD1

Product Clone Name: GG-Y

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-395

Epitope Target: HORMAD1

Epitope Species: human

Product Reactivity/Detection: HORMAD1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for HORMAD1 Antibody (GG-Y): N/A