EMILIN-5 Activators
EMILIN-5, known scientifically as elastin microfibril interfacer 3, is a protein encoded by the EMILIN3 gene in humans. It plays a critical role in the structural organization and integrity of the extracellular matrix (ECM), a complex network of proteins that provides support and regulates intercellular communication. EMILIN-5 has been shown to be involved in the interaction with other ECM proteins, such as collagens, and its expression is crucial for maintaining the proper architecture and function of various tissues. The regulation of EMILIN-5 is of significant interest in the field of cellular biology, as it pertains to the dynamic balance of the ECM and the body's ability to respond to physiological changes. Understanding the mechanisms that govern the expression of EMILIN-5 could provide valuable insights into the maintenance of tissue homeostasis and the cellular response to environmental stresses.
Several chemical compounds have been identified as potential activators that could influence the expression of EMILIN-5. For instance, retinoic acid, a metabolite of vitamin A, has properties that may upregulate EMILIN-5, possibly through its interaction with nuclear receptors that modulate gene expression linked to the ECM. Compounds like 5-Azacytidine and trichostatin A, which are known to act as epigenetic modifiers, might also increase the expression of EMILIN-5 by altering the accessibility of its gene promoter to transcriptional machinery. Moreover, antioxidants such as vitamin C and epigallocatechin gallate could stimulate EMILIN-5 expression by engaging with cellular defense mechanisms against oxidative stress, thereby promoting the synthesis of ECM components. The flavonoid fisetin is another compound that may enhance EMILIN-5 levels by activating transcription factors involved in the stress response. Other molecules, including dexamethasone and sodium butyrate, might influence EMILIN-5 expression through their capacity to modulate inflammatory responses and chromatin structure, respectively. Collectively, these activators represent a diverse array of chemical entities that could potentially induce the expression of EMILIN-5, each through a unique pathway reflective of the intricate regulation of gene expression within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid could potentially upregulate EMILIN-5 through receptor-mediated enhancement of collagen synthesis pathways, which are closely related to extracellular matrix formation. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
By inhibiting DNA methylation, 5-Azacytidine may increase EMILIN-5 expression by demethylating gene promoter regions, leading to transcriptional activation of its coding sequence. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A might stimulate EMILIN-5 expression by altering chromatin structure, specifically increasing histone acetylation and thus promoting gene accessibility for transcription factors. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $46.00 | 5 | |
L-Ascorbic acid may upregulate EMILIN-5 by serving as a cofactor for prolyl hydroxylase, an enzyme critical for the hydroxylation of proline residues in collagen, thereby stabilizing the extracellular matrix where EMILIN-5 is localized. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin Gallate could stimulate EMILIN-5 expression by activating antioxidant response elements within the promoter region of the gene, leading to an upsurge in transcriptional activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin might upregulate EMILIN-5 by stimulating nuclear translocation of transcription factors that bind to the EMILIN-5 gene promoter, thereby increasing its transcription. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone may increase EMILIN-5 expression by attenuating pro-inflammatory cytokine signaling, leading to a conducive environment for extracellular matrix protein synthesis. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol could induce EMILIN-5 expression through the activation of the SIRT1 signaling pathway, which has been associated with enhanced transcription of various genes involved in cellular stress responses. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
Hydrogen peroxide may indirectly stimulate EMILIN-5 transcription as a byproduct of cellular responses to oxidative stress, which often includes increased synthesis of structural proteins in the extracellular matrix. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate might upregulate EMILIN-5 by increasing histone acetylation levels, leading to a decondensed chromatin structure and greater accessibility of transcriptional machinery to the EMILIN-5 gene. | ||||||