CYLD Activators
CYLD activators are a diverse array of chemical compounds that indirectly enhance the functional activity of CYLD, a protein that plays a pivotal role in the negative regulation of NF-κB signaling through its deubiquitinating function. Compounds such as Forskolin, Resveratrol, and Epigallocatechin gallate (EGCG) facilitate the activity of CYLD by modulating pathways that intersect with its regulatory control. Forskolin augments intracellular cAMP, which activates PKA and can lead to phosphorylation of proteins within the NF-κB pathway, thus potentially enhancing CYLD's deubiquitinating activity. Resveratrol activates SIRT1, which may deacetylate proteins and modify the signal transduction leading to a supportive environment for CYLD's function. EGCG, as an NF-κB inhibitor, creates a cellular context that could potentiate CYLD's negative regulation of this pathway.
Moreover, additional compounds like Parthenolide, Sulforaphane, and Curcumin contribute to the activation of CYLD by manipulating specific signaling mechanisms that indirectly affect its activity. Parthenolide inhibits the phosphorylation of IκB, facilitating CYLD's function by reducing the competitive ubiquitination of NF-κB pathway components. Sulforaphane activates Nrf2, leading to an oxidative stress response that can elevate CYLD's regulatory role in protein ubiquitination. Curcumin suppresses NF-κB activation, which synergizes with CYLD's intrinsic activity as a deubiquitinase to maintain homeostatic control of the pathway. Collectively, these activators, through their targeted biochemical actions, fortify the role of CYLD in cellular signaling without the necessity of upregulating its expression or direct stimulation.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin increases intracellular cAMP levels which can activate protein kinase A (PKA). PKA can phosphorylate certain proteins, potentially leading to the activation of CYLD's deubiquitinating activity on specific substrates involved in NF-κB signaling. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Parthenolide inhibits the NF-κB pathway by preventing IκB phosphorylation, leading to an accumulation of IκB and reduced NF-κB activity. CYLD, as a negative regulator of NF-κB, may have its function enhanced by the reduced ubiquitination of signaling components due to the action of Parthenolide. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates sirtuin 1 (SIRT1), which can deacetylate proteins and influence the NF-κB pathway. As CYLD is a deubiquitinase that negatively regulates NF-κB, Resveratrol may indirectly enhance CYLD's activity by modulating the pathway's negative regulation. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane activates the Nrf2 signaling pathway, which is involved in the cellular response to oxidative stress. CYLD can be activated by oxidative stress, as it is involved in the removal of polyubiquitin chains from key signaling proteins, thus enhancing its regulatory role. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin inhibits NF-κB activation by suppressing the phosphorylation and degradation of IκBα. This action can indirectly enhance the regulatory effect of CYLD on the NF-κB signaling pathway. | ||||||
Piperlongumine | 20069-09-4 | sc-364128 | 10 mg | $107.00 | ||
Piperlongumine increases ROS production, which can modulate various signaling pathways including NF-κB. By inducing oxidative stress, it may amplify CYLD's role in counteracting the ubiquitination of NF-κB pathway components. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin inhibits the phosphorylation of IκBα and subsequent activation of NF-κB. This flavonoid thereby has the potential to enhance the inhibitory effect of CYLD on the NF-κB pathway. | ||||||
Caffeic acid phenethyl ester | 104594-70-9 | sc-200800 sc-200800A sc-200800B | 20 mg 100 mg 1 g | $71.00 $296.00 $612.00 | 19 | |
CAPE blocks NF-κB activation by preventing the phosphorylation of IκBα. This action can potentiate the negative regulatory role of CYLD in the NF-κB signaling pathway. | ||||||
Capsazepine | 138977-28-3 | sc-201098 sc-201098A | 5 mg 25 mg | $148.00 $459.00 | 11 | |
Capzasin-P activates transient receptor potential vanilloid 1 (TRPV1), which can lead to an increase in intracellular calcium levels and activation of calcium-dependent signaling pathways. These pathways can intersect with NF-κB signaling, thus indirectly enhancing CYLD's activity. | ||||||
Oltipraz | 64224-21-1 | sc-205777 sc-205777A | 500 mg 1 g | $286.00 $622.00 | ||
Oltipraz activates Nrf2, which is part of the cellular antioxidant response. Activation of Nrf2 can modulate NF-κB signaling, potentially enhancing the role of CYLD in controlling the ubiquitination status of pathway components. | ||||||