ICMT Inhibitors
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(E,E)-Farnesyl Thiol | 138077-74-4 | sc-497781 | 100 mg | $420.00 | ||
(E,E)-Farnesyl Thiol functions as an isoprenylcysteine carboxyl methyltransferase (ICMT) substrate, playing a crucial role in post-translational modifications. Its unique thiol group facilitates nucleophilic attacks, enabling efficient methylation of isoprenylated proteins. This compound exhibits distinct reactivity patterns, influencing protein localization and stability. The kinetics of its interactions suggest a rapid turnover, impacting cellular signaling pathways and protein interactions significantly. | ||||||
Manumycin A | 52665-74-4 | sc-200857 sc-200857A | 1 mg 5 mg | $215.00 $622.00 | 5 | |
Manumycin A is a farnesyltransferase inhibitor that might decrease ICMT expression by reducing the need for its enzymatic activity. | ||||||
Lovastatin | 75330-75-5 | sc-200850 sc-200850A sc-200850B | 5 mg 25 mg 100 mg | $28.00 $88.00 $332.00 | 12 | |
Lovastatin inhibits HMG-CoA reductase, potentially decreasing isoprenoid biosynthesis and subsequent demand for ICMT activity. | ||||||
Simvastatin | 79902-63-9 | sc-200829 sc-200829A sc-200829B sc-200829C | 50 mg 250 mg 1 g 5 g | $30.00 $87.00 $132.00 $434.00 | 13 | |
Simvastatin, another HMG-CoA reductase inhibitor, may lead to lower levels of substrates for prenylation, indirectly affecting ICMT. | ||||||
Pravastatin | 81093-37-0 | sc-222188 | 50 mg | $400.00 | 1 | |
Pravastatin is part of the statin class of chemicals and might decrease ICMT expression by limiting the supply of isoprenoids. | ||||||
Atorvastatin | 134523-00-5 | sc-337542A sc-337542 | 50 mg 100 mg | $252.00 $495.00 | 9 | |
Atorvastatin is an HMG-CoA reductase inhibitor, which could theoretically reduce ICMT expression by decreasing prenylation substrates. | ||||||
Rosuvastatin | 287714-41-4 | sc-481834 | 10 mg | $142.00 | 8 | |
As a statin, Rosuvastatin might indirectly downregulate ICMT by limiting the availability of isoprenoid intermediates. | ||||||
Alendronate acid | 66376-36-1 | sc-337520 | 5 g | $135.00 | 2 | |
Alendronate inhibits farnesyl diphosphate synthase, potentially reducing prenylation and thus ICMT expression. | ||||||
Zoledronic acid, anhydrous | 118072-93-8 | sc-364663 sc-364663A | 25 mg 100 mg | $90.00 $251.00 | 5 | |
Zoledronic acid inhibits farnesyl diphosphate synthase which could lead to decreased demand for ICMT activity. | ||||||
Risedronic acid | 105462-24-6 | sc-203239 | 100 mg | $107.00 | 2 | |
Risedronate inhibits farnesyl diphosphate synthase, potentially reducing the substrate availability for ICMT. | ||||||