FAST Inhibitors
FAST inhibitors belong to a class of chemical compounds specifically designed to target and modulate the activity of the FAST protein, which stands for "Fas-activated serine-threonine kinase." FAST is a relatively newly discovered protein that plays a role in cellular processes, particularly in cell signaling pathways associated with apoptosis, or programmed cell death. Apoptosis is a fundamental mechanism in multicellular organisms, regulating tissue development, immune responses, and the elimination of damaged or potentially harmful cells. Inhibitors designed to target FAST are primarily employed in molecular and cellular biology research to investigate the functional properties and regulatory mechanisms associated with this protein's role in apoptosis signaling.
The development of FAST inhibitors typically involves a combination of biochemical, biophysical, and structural approaches aimed at identifying or designing molecules that can selectively interact with FAST and modulate its activity within apoptosis signaling pathways. By inhibiting FAST, these compounds can potentially disrupt its role in regulating apoptosis, affecting cell survival and death decisions. Researchers use FAST inhibitors to explore the intricate roles played by this protein in cellular processes, attempting to unravel its contributions to apoptosis pathways, immune cell responses, and tissue homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D binds to DNA and inhibits RNA polymerase, which could reduce FASTK mRNA synthesis and thus its protein levels. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Cycloheximide inhibits eukaryotic protein synthesis by interfering with the translocation step in protein synthesis, potentially decreasing FASTK protein levels. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
5-Fluorouracil is metabolized to compounds that can be incorporated into RNA and disrupt its processing, possibly affecting FASTK expression indirectly. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine can elevate lysosomal pH and affect protein degradation pathways, which may influence FASTK protein stability and expression. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
As a glycolysis inhibitor, 2-Deoxy-D-glucose may disrupt cellular metabolism, potentially downregulating FASTK expression due to energy stress. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG-132 is a proteasome inhibitor that could lead to reduced degradation of proteins that regulate FASTK expression, indirectly affecting its levels. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that could alter chromatin structure and modulate the transcription of various genes, including potentially FASTK. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
SAHA is another histone deacetylase inhibitor that may change gene expression profiles, possibly affecting FASTK expression. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
α-Amanitin is an inhibitor of RNA polymerase II which could lead to a decrease in mRNA synthesis, affecting the levels of proteins such as FASTK. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin inhibits DNA topoisomerase I, which could result in reduced transcription and therefore decrease FASTK expression. | ||||||