FAST Activators
FAST (Fas Activated Serine/Threonine Kinase) activators represent a class of small molecules or compounds that play a pivotal role in cellular signaling pathways. Fas Activated Serine/Threonine Kinase, abbreviated as FAST, is a crucial enzyme within the intracellular signaling cascade primarily associated with apoptosis, or programmed cell death. FAST activators, therefore, are molecules capable of modulating the activity of this kinase, thereby influencing cell fate decisions and maintaining cellular homeostasis.
At the molecular level, FAST activators typically interact with the kinase's active site or its regulatory domains, altering its conformation and activity. These compounds often act as agonists, stimulating FAST kinase activation, or, in some cases, as antagonists, inhibiting its function. The activation of FAST kinase is a key event in the Fas-mediated apoptotic pathway, which is essential for the removal of damaged or unwanted cells in multicellular organisms. By manipulating FAST kinase activity, these activators can regulate the delicate balance between cell survival and death.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Doxorubicin triggers DNA damage response pathways due to its DNA-intercalating properties. This may indirectly activate FASTK as a downstream effect of DNA damage. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel induces microtubule stabilization, causing cellular stress. FASTK activation may occur as a response to this stress or through associated pathways. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin causes DNA damage and triggers DNA damage response pathways. FASTK activation may occur indirectly as part of the cellular response to DNA damage. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
Hydrogen peroxide generates oxidative stress, impacting gene expression and potentially activating FASTK or related pathways indirectly through oxidative stress responses. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $66.00 $101.00 $143.00 | 85 | |
Mitomycin C crosslinks DNA, leading to DNA damage response activation. FASTK activation may occur indirectly as part of the response to DNA damage. | ||||||
Arsenic(III) oxide | 1327-53-3 | sc-210837 sc-210837A | 250 g 1 kg | $89.00 $228.00 | ||
Arsenic trioxide can induce oxidative stress and cellular damage responses. This oxidative stress may indirectly activate FASTK or related pathways as a cellular stress response. | ||||||