Date published: 2026-4-4

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ZO Antibodies

Santa Cruz Biotechnology provides a broad selection of ZO Antibodies, specifically targeting zonula occludens proteins, which play a crucial role in maintaining tight junction integrity and cellular barrier function. ZO Antibodies are suitable for western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Zonula occludens proteins are essential for the regulation of paracellular permeability and are involved in cell signaling pathways that influence tissue homeostasis. ZO protein dysfunction is associated with various diseases, including cancer and inflammatory disorders, making them significant targets for therapeutic intervention. The study of zonula occludens proteins can provide insights into the mechanisms of disease progression and potential treatment strategies. Understanding ZO protein expression patterns and interactions helps reveal their role in maintaining cellular barriers and regulating cell-to-cell communication. Investigating zonula occludens proteins advances knowledge about tissue organization and development. Research into ZO proteins contributes to understanding various pathological conditions affecting barrier function. Santa Cruz Biotechnology monoclonal antibodies for ZO proteins support researchers worldwide in advancing scientific understanding of cellular barriers and disease mechanisms.

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ZO Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

ZO-1 Antibody (R40.76)

sc-33725rat IgG2a(r)WB, IP, IF, IHC(P)m, r, h
216
(50)

ZO-2 Antibody (E-3)

sc-515115mouse IgM κ789-813 (r)WB, IP, IF, ELISAm, r, h
5
(6)

ZO-2 Antibody (E-5)

sc-514557mouse IgG1 κ1145-1167 (h)WB, IP, IF, ELISAh

new

(0)

ZO-3 Antibody (1E8)

sc-293313mouse IgG2a κ868-952 (h)WB, IP, ELISAh

new

(2)

ZO CRISPR Knockout, HDR and Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

ZO-1 CRISPR/Cas9 KO Plasmid (h)

sc-400196hGene KnockoutGFP0
(0)

ZO-1 HDR Plasmid (h)

sc-400196-HDRhHomology Directed RepairPuromycin0
(0)

ZO-1 Double Nickase Plasmid (h)

sc-400196-NIChGene KnockoutPuromycin0
(0)

ZO-1 Double Nickase Plasmid (h2)

sc-400196-NIC-2hGene KnockoutPuromycin0
(0)

ZO-1 Double Nickase Plasmid (m)

sc-423407-NICmGene KnockoutPuromycin0
(0)

ZO-2 CRISPR/Cas9 KO Plasmid (h)

sc-401395hGene KnockoutGFP0
(0)

ZO CRISPR Activation Products

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

ZO-1 CRISPR Activation Plasmid (h)

sc-400196-ACThGene ActivationPuro, Blast, Hygro0
(0)

ZO siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

ZO-1 siRNA (h)

sc-29829hGene SilencingN/A
6
(0)

ZO-1 siRNA (h2)

sc-44288hGene SilencingN/A0
(1)

ZO-1 shRNA Plasmid (h)

sc-29829-SHhGene SilencingPuromycin
6
(0)

ZO-1 shRNA Plasmid (h2)

sc-44288-SHhGene SilencingPuromycin0
(1)

ZO-1 shRNA (h) Lentiviral Particles

sc-29829-VhGene SilencingPuromycin
6
(0)

ZO-1 shRNA (h2) Lentiviral Particles

sc-44288-VhGene SilencingPuromycin0
(1)

ZO-1 siRNA (m)

sc-29832mGene SilencingN/A
1
(0)

ZO-1 shRNA Plasmid (m)

sc-29832-SHmGene SilencingPuromycin
1
(0)

ZO-1 shRNA (m) Lentiviral Particles

sc-29832-VmGene SilencingPuromycin
1
(0)

ZO-2 siRNA (h)

sc-29833hGene SilencingN/A
2
(1)

ZO-2 shRNA Plasmid (h)

sc-29833-SHhGene SilencingPuromycin
2
(1)

ZO-2 shRNA (h) Lentiviral Particles

sc-29833-VhGene SilencingPuromycin
2
(1)

ZO-2 siRNA (m)

sc-29926mGene SilencingN/A0
(0)

ZO-2 shRNA Plasmid (m)

sc-29926-SHmGene SilencingPuromycin0
(0)

ZO-2 shRNA (m) Lentiviral Particles

sc-29926-VmGene SilencingPuromycin0
(0)

ZO-3 siRNA (h)

sc-43538hGene SilencingN/A
1
(0)

ZO-3 shRNA Plasmid (h)

sc-43538-SHhGene SilencingPuromycin
1
(0)

ZO-3 shRNA (h) Lentiviral Particles

sc-43538-VhGene SilencingPuromycin
1
(0)

ZO-3 siRNA (m)

sc-43539mGene SilencingN/A0
(0)

ZO-3 shRNA Plasmid (m)

sc-43539-SHmGene SilencingPuromycin0
(0)

ZO-3 shRNA (m) Lentiviral Particles

sc-43539-VmGene SilencingPuromycin0
(0)