Smad7 Antibody (Z8-B): sc-101152

Smad7 Antibody (Z8-B) is a mouse monoclonal IgG2a kappa light chain antibody that detects Smad7 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-Smad7 antibody (Z8-B) is available in a non-conjugated form, allowing for versatile experimental use. Smad7 plays a crucial role in the regulation of TGFβ (transforming growth factor beta) signaling pathways, acting as a negative regulator that inhibits the phosphorylation of receptor-regulated Smads, thereby preventing their activation and subsequent transcriptional activity. This function is vital for maintaining cellular homeostasis and preventing excessive signaling that can lead to pathological conditions such as fibrosis and cancer. The ability of Smad7 to modulate TGFβ signaling highlights its importance in various biological processes, including development, immune response, and tissue repair. Smad7 monoclonal antibody (Z8-B) enables researchers to gain insights into the intricate mechanisms of TGFβ signaling and its implications in health and disease.

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Smad7 Antibody (Z8-B) has 30 citations in a variety of scientific publications.

Primary antibodies like Anti-Smad7 Antibody (Z8-B) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Smad7 Antibody (Z8-B) Specifications

Alternate Product Name: Smad7

Product Clone Name: Z8-B

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 160-261

Epitope Target: Smad7

Epitope Species: human

Product Reactivity/Detection: Smad7

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 30 citations in various scientific publications

Available Conjugates/Forms for Smad7 Antibody (Z8-B): N/A

The preferred Smad7 antibody is Smad7 Antibody (B-8): sc-365846.