SIRT1 Antibody (33.36): sc-135792

SIRT1 Antibody (33.36) is a mouse monoclonal IgG1 kappa light chain antibody engineered to recognize recombinant human SIRT1 protein, enabling the detection of SIRT1 in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA) applications. SIRT1, also called SIR2, SIR2L1, and SIR2alpha, is a crucial member of the evolutionarily conserved sirtuin family, possessing a sophisticated structure that includes a large Rossmann-fold domain responsible for binding NAD⁺ and a smaller zinc-binding domain essential for deacetylase activity. This structural configuration allows SIRT1 to interact with a diverse array of substrates, including histones and key transcription factors, thereby regulating vital cellular processes such as gene expression, DNA repair, metabolism, and aging. The precise architecture of SIRT1 is fundamental to function, ensuring substrate specificity and enzymatic efficiency, which are critical for maintaining cellular homeostasis and responding to stress signals. Anti-SIRT1 antibody (33.36) facilitates detailed structural and functional studies, making SIRT1 (33.36) monoclonal antibody an indispensable tool for researchers investigating the molecular mechanisms underlying age-related diseases, cancer, and metabolic disorders. SIRT1 (33.36) antibody supports advanced research into the pivotal roles of SIRT1 in cellular physiology and pathology, ultimately contributing to the development of targeted therapeutic strategies aimed at modulating SIRT1′s regulatory functions.

The preferred SIRT1 antibody is SIRT1 Antibody (B-10): sc-74504.