Molecular structure of Ro 8-4304 Hydrochloride, CAS Number: 1312991-77-7
Ro 8-4304 Hydrochloride (CAS 1312991-77-7)
Alternate Names:
4-[3-[4-(4-Fluorophenyl)-1,2,3,6-tetrahydro-1(2H)-pyridinyl]-2-hydroxypropoxy]benzamide hydrochloride
Application:
Ro 8-4304 Hydrochloride is a NMDA receptor antagonist
CAS Number:
1312991-77-7
Purity:
≥99%
Molecular Weight:
406.88
Molecular Formula:
C21H23FN2O3•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
NMDA receptor antagonist (IC50 = 0.4 μM) that displays > 100 fold selectivity for NR2B-containing receptors over NR2A-containing receptors. Displays an activity-dependent mechanism of NMDA antagonism and is competitive with respect to spermine.
Ro 8-4304 Hydrochloride (CAS 1312991-77-7) References
Kew et al (1998) State-dependent NMDA receptor antagonism by Ro 8-4304, a novel NR2B selective, non-competitive, voltage-independent antagonist. Br.J.Pharmacol. 123 463. Kew and Kemp (1998) An allosteric interaction between the NMDA receptor polyamine and ifenprodil sites in rat cultured cortical neurones. J.Physiol. 512 17.Inhibitor of:
NMDA epsilon 2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ro 8-4304 Hydrochloride, 10 mg | sc-204241 | 10 mg | $149.00 | |||
| US: Only available in the US | ||||||
Ro 8-4304 Hydrochloride, 50 mg | sc-204241A | 50 mg | $630.00 | |||
| US: Only available in the US | ||||||