PLAP Antibody (HD 11F7): sc-53414

PLAP Antibody (HD 11F7) is a mouse monoclonal IgG2b light chain antibody that detects placental alkaline phosphatase (PLAP) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). PLAP is a 530 amino acid glycoprotein that plays a crucial role in various physiological processes, particularly during pregnancy, where PLAP is predominantly expressed in the placenta and found in the serum of pregnant women. PLAP is not only vital for the hydrolysis of phosphomonoesters into inorganic phosphate and alcohol but also assists in guiding migratory cells and transporting essential molecules, including fatty acids and immunoglobulins, across the plasma membrane. The presence of PLAP in ectopic tissues, such as certain cancers of the ovary and testis, highlights PLAP′s potential as a biomarker for malignancies, making anti-PLAP antibody (HD 11F7) an invaluable tool for researchers studying both normal physiological conditions and pathological states. Additionally, the three tissue-specific alkaline phosphatases identified in humans—PLAP, germ cell alkaline phosphatase (GCAP), and intestinal alkaline phosphatase—are highly homologous, sharing 90-98% sequence identity, and are clustered on chromosome 2q, further emphasizing PLAP′s importance in both developmental biology and cancer research.

The preferred TNAP antibody is TNAP Antibody (F-4): sc-166261.