PLAP Activators
Common PLAP Activators include, but are not limited to Dexamethasone CAS 50-02-2, β-Estradiol CAS 50-28-2, Progesterone CAS 57-83-0, Forskolin CAS 66575-29-9 and Genistein CAS 446-72-0.
PLAP, or Placental Alkaline Phosphatase, is an enzyme that belongs to the family of alkaline phosphatases. PLAP Activators refer to substances or mechanisms that can influence or enhance the activity of this specific enzyme. Alkaline phosphatases are a group of enzymes that catalyze the hydrolysis of phosphate esters in an alkaline environment. PLAP is a variant of alkaline phosphatase found predominantly in the placenta during pregnancy, although it can also be present in other tissues in smaller amounts. Its precise role in placental function is not fully understood, but it is believed to be involved in the regulation of phosphate transport and metabolism, which is crucial for fetal development.
Understanding PLAP and its activators is significant in the context of pregnancy and reproductive biology. PLAP levels in maternal serum or urine can be measured as a marker for certain prenatal conditions, such as Down syndrome, as abnormal levels may indicate issues with fetal development. Activators within this class could influence PLAP activity and, therefore, the accuracy of these diagnostic tests. Moreover, studying PLAP activators may shed light on the regulation of phosphate metabolism in placental tissues, which could have implications for understanding normal and pathological pregnancy outcomes. In summary, PLAP Activators represent a category of substances or processes that can modulate the activity of PLAP, an enzyme with relevance to pregnancy monitoring and the biology of placental development.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
This glucocorticoid can influence PLAP expression as part of its broader effects on gene expression and differentiation. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
As a hormone, estrogen can influence the expression of various genes, potentially including PLAP, especially in placental and tumor contexts. | ||||||
Progesterone | 57-83-0 | sc-296138A sc-296138 sc-296138B | 1 g 5 g 50 g | $20.00 $52.00 $298.00 | 3 | |
Progesterone, another hormone, might modulate PLAP expression, especially in the context of placental development and function. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, elevating cAMP levels, which might influence PLAP expression. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
HDAC inhibitor that opens chromatin structure at the PLAP locus, allowing improved access for transcription factors. | ||||||
Troglitazone | 97322-87-7 | sc-200904 sc-200904B sc-200904A | 5 mg 10 mg 25 mg | $110.00 $204.00 $435.00 | 9 | |
PPARγ agonist that activates PPRE sites upstream of PLAP to initiate mRNA synthesis. | ||||||
(+)-α-Tocopherol | 59-02-9 | sc-214454 sc-214454A sc-214454B sc-214454C | 10 g 25 g 100 g 1 kg | $43.00 $62.00 $141.00 $430.00 | ||
Antioxidant that may reduce methylation of CpG islands near PLAP, impairing recruitment of methyl-CpG-binding proteins and relieving repression. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
DNMT inhibitor that prevents methylation marks repressing PLAP, enabling transcriptional machinery binding. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
HDAC inhibitor favoring histone acetylation profiles at PLAP associated regulatory regions. | ||||||
Selenium | 7782-49-2 | sc-250973 | 50 g | $62.00 | 1 | |
Antioxidant associated with altered methylation patterns near PLAP that oppose transcriptional silencing. | ||||||